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Normalized Accurate Measurement of Longitudinal Brain Change
Purpose Quantitative measurement of change in brain size and shape (e.g., to estimate atrophy) is an important current area of research. New methods of change analysis attempt to improve robustness,Expand
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Imaging axonal damage of normal-appearing white matter in multiple sclerosis.
The current study was designed to determine the relative distribution of decreases of N-acetylasparate (NAA), a marker of axonal damage, between lesions and normal-appearing white matter of patientsExpand
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Evaluating and reducing the impact of white matter lesions on brain volume measurements
MR‐based measurements of brain volumes may be affected by the presence of white matter (WM) lesions. Here, we assessed how and to what extent this may happen for WM lesions of various sizes andExpand
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Evidence of early cortical atrophy in MS
Objective: To assess cortical gray matter (GM) changes in MS and establish their relevance to clinical disability and to inflammatory changes of white matter (WM) in patients with theExpand
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Chemical pathology of acute demyelinating lesions and its correlation with disability
We report the chemical pathological changes on magnetic resonance spectroscopic images of 4 patients, each of whom had a single large demyelinating plaque. The patients were followed from soon afterExpand
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Summary In patients presenting with a clinically isolated syndrome (CIS), magnetic resonance imaging (MRI) can support and substitute clinical information for multiple sclerosis (MS) diagnosisExpand
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Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability.
OBJECTIVE To assess axonal damage and its contribution to disability at different stages of multiple sclerosis (MS). BACKGROUND Recent in vivo imaging and in situ pathologic studies haveExpand
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Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study.
It has been difficult to establish a strong correlation between total brain T2-weighted lesion volume on MRI and clinical disability in multiple sclerosis, in part because of the lack of pathologicalExpand
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Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis.
BACKGROUND A significant inflammatory pathologic disorder in the cortex of patients with multiple sclerosis (MS) has been demonstrated by ex vivo studies. OBJECTIVE To determine the frequency, timeExpand
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Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes
Objective: To assess the time course of brain atrophy and the difference across clinical subtypes in multiple sclerosis (MS). Methods: The percent brain volume change (PBVC) was computed on existingExpand
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