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Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap
Although our knowledge of the pathophysiology of schizophrenia has increased, treatments for this devastating illness remain inadequate. Here, we critically assess rodent models and behavioural endExpand
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Sustained NMDA receptor hypofunction induces compromised neural systems integration and schizophrenia-like alterations in functional brain networks.
Compromised functional integration between cerebral subsystems and dysfunctional brain network organization may underlie the neurocognitive deficits seen in psychiatric disorders. ApplyingExpand
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Modafinil reverses phencyclidine-induced deficits in cognitive flexibility, cerebral metabolism, and functional brain connectivity.
OBJECTIVE In the present study, we employ mathematical modeling (partial least squares regression, PLSR) to elucidate the functional connectivity signatures of discrete brain regions in order toExpand
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Assessing the contribution of ecosystem services to human wellbeing: a disaggregated study in western Rwanda.
Lack of attention to social complexity has created a gap between current ecosystem service research and the kind of insights needed to inform ecosystem management in the tropics. To contribute toExpand
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Green Revolution in Sub-Saharan Africa: Implications of Imposed Innovation for the Wellbeing of Rural Smallholders
Green Revolution policies are again being pursued to drive agricultural growth and reduce poverty in Sub-Saharan Africa. However conditions have changed since the well-documented successes of theExpand
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Subanaesthetic ketamine treatment alters prefrontal cortex connectivity with thalamus and ascending subcortical systems.
BACKGROUND Acute treatment with subanaesthetic doses of NMDA receptor antagonists, such as ketamine, provides a translational model with relevance to many of the symptoms of schizophrenia. PreviousExpand
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Social-ecological outcomes of agricultural intensification
Land-use intensification in agrarian landscapes is seen as a key strategy to simultaneously feed humanity and use ecosystems sustainably, but the conditions that support positive social-ecologicalExpand
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Wild food collection and nutrition under commercial agriculture expansion in agriculture-forest landscapes
Wild food constitutes a substantial part of household food consumption around the world, but rapid land use changes influence the availability of wild foods, which has implications for smallholders'Expand
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Justice and conservation: The need to incorporate recognition
In light of the Aichi target to manage protected areas equitably by 2020, we ask how the conservation sector should be incorporating concerns for social justice. We focus in particular onExpand
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Assessing Equity in Protected Area Governance: Approaches to Promote Just and Effective Conservation
With the inclusion of equity concerns in Aichi Target 11 of the Convention on Biological Diversity, equitable management has become an important objective for the world's protected areas. The wayExpand
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