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Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome
TLDR
This study provides the rationale for a goal‐directed approach to the management of patients with cirrhosis and AH, in which the assessment of neutrophil function may be an important biomarker to select patients for immunosuppressive therapy.
Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection
TLDR
It is demonstrated that CD8 T cells from CHB patients, regardless of their antigen specificity, were impaired in their ability to produce interleukin-2 and proliferate upon TCR-dependent stimulation, and evidence for depletion of arginine in the inflamed hepatic microenvironment is provided as a potential mechanism for these defects in globalCD8 T cell signaling and function.
Endotoxemia produces coma and brain swelling in bile duct ligated rats
TLDR
Injection of LPS into cirrhotic rats induces pre‐coma and exacerbates cytotoxic edema because of the synergistic effect of hyperammonemia and the induced inflammatory response, which supports an important role for the nitrosation of brain proteins.
Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells
TLDR
The capacity of expanded arginase-expressing gMDSCs to regulate liver immunopathology in HBV infection is demonstrated, providing in vitro and ex vivo evidence that gM DSCs potently inhibited T cells in a partially arkinase-dependent manner.
Remote ischaemic preconditioning of the hind limb reduces experimental liver warm ischaemia–reperfusion injury
TLDR
The effect of brief remote ischaemia to the limb in reducing early liver warm IRI is determined.
Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis
TLDR
Alcoholic hepatitis patients have higher portal pressures associated with increased ADMA, which may result from both decreased breakdown (decreased hepatic dimethylarginine‐dimethylamino‐hydrolase) and/or increased production.
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