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Do functional relationships exist between 5-HT1A and 5-HT2 receptors?
TLDR
A 5- HT1A inhibitory action on the 5-HT2 receptor-mediated response when induced by its selective agonist (+/-)-DOI is proposed. Expand
Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system.
TLDR
The potential to utilize the endocannabinoid system in the treatment of these frequently debilitating conditions is discussed, and the production of endogenous cannabinoids acting centrally is discovered. Expand
Δ9-Tetrahydrocannabinol and Synthetic Cannabinoids Prevent Emesis Produced by the Cannabinoid CB1 Receptor Antagonist/Inverse Agonist SR 141716A
  • N. Darmani
  • Chemistry, Medicine
  • Neuropsychopharmacology
  • 1 February 2001
TLDR
The results suggest that the antiemetic activity of Δ9-THC and its synthetic analogs reside in their ability to stimulate the cannabinoid CB1 receptor, which implicates an important role for endogenous cannabinoids in emetic circuits. Expand
Involvement of other neurotransmitters in behaviors induced by the cannabinoid CB1 receptor antagonist SR 141716A in naive mice
TLDR
Since SR 141716A lacks affinity for the discussed receptors, it appears that the induction of the cited behaviors probably involve indirect activation of their respective neurotransmitter systems. Expand
Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew
TLDR
It is reported here that cisplatin causes dose- and time-dependent increases in brain tissue levels of 2-AG but not anandamide in this vomiting species, and the established notion that 2- AG may produce some of its effects, including emesis, via downstream metabolites produced independently of FAAH is supported. Expand
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.
  • N. Darmani
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2002
TLDR
2-AG is an efficacious endogenous emetogenic cannabinoid involved in vomiting circuits, the emetic action of 2-AG and the antiemetic effects of tested cannabinoids are mediated via CB(1) receptors, and the emetically effects of 1-AG occur in lower doses relative to its locomotor suppressant actions. Expand
The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2.
  • N. Darmani
  • Chemistry, Medicine
  • European journal of pharmacology
  • 26 October 2001
TLDR
The results suggest that WIN 55, 212-2 reduces both emesis and indeces of locomotion via the stimulation of cannabinoid CB1 receptors, since reduction in the frequency of vomiting occurred at lower doses relative to its sedative actions. Expand
Central and peripheral mechanisms contribute to the antiemetic actions of delta-9-tetrahydrocannabinol against 5-hydroxytryptophan-induced emesis.
TLDR
The results indicate that delta-9-THC probably acts pre- and postsynaptically to attenuate emesis produced by indirect and direct acting 5-HT(3) receptor agonists via both central and peripheral mechanisms. Expand
Delta-9-tetrahydrocannabinol differentially suppresses cisplatin-induced emesis and indices of motor function via cannabinoid CB1 receptors in the least shrew
  • N. Darmani
  • Medicine, Chemistry
  • Pharmacology Biochemistry and Behavior
  • 1 May 2001
TLDR
Investigation of cannabinoid receptor mechanisms by which Delta(9)-THC produces its antiemetic effects against cisplatin-induced emesis as well as its cannabimimetic activity profile (motor reduction) in the least shrew finds it is a more potent anti-emetic agent. Expand
Reversal of SR 141716A-induced head-twitch and ear-scratch responses in mice by Δ9-THC and other cannabinoids
TLDR
The present data show that cannabinoids of diverse structure prevent SR 141716A-induced HTR and ESR, and inhibition of these behaviors by cannabinoids could be used as a new index of cannabimimetic activity. Expand
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