• Publications
  • Influence
Extensive Cortical Rewiring after Brain Injury
TLDR
The results suggest that M1 injury results in axonal sprouting near the ischemic injury and the establishment of novel connections within a distant target, and support the hypothesis that, after a cortical injury, such as occurs after stroke, cortical areas distant from the injury undergo major neuroanatomical reorganization. Expand
Post-infarct cortical plasticity and behavioral recovery using concurrent cortical stimulation and rehabilitative training: A feasibility study in primates
TLDR
Results support the feasibility of using a therapy approach combining peri-infarct electrical stimulation with rehabilitative training to alleviate chronic motor deficits and promote recovery from cortical ischemic injury. Expand
Vicarious Function of Remote Cortex following Stroke: Recent Evidence from Human and Animal Studies
  • N. Dancause
  • Psychology, Medicine
  • The Neuroscientist : a review journal bringing…
  • 1 December 2006
TLDR
The author reviews human and animal studies that show the plastic potential of the adult CNS after stroke, highlighting the vicarious role of the premotor cortex in the recovery of motor control. Expand
Corticospinal Neurons in Macaque Ventral Premotor Cortex with Mirror Properties: A Potential Mechanism for Action Suppression?
TLDR
A novel finding is that many PTNs showed complete suppression of discharge during action observation, while firing actively when the monkey grasped food rewards, and it is speculated that this suppression of PTN discharge might be involved in the inhibition of self-movement duringaction observation. Expand
Effects of small ischemic lesions in the primary motor cortex on neurophysiological organization in ventral premotor cortex.
TLDR
The results suggest that after a lesion in the M1 DFL, the induction of representational plasticity in PMv, as evaluated using intracortical microstimulation, is related more to the size of the lesion than to the disruption of its intrACortical connections. Expand
Ipsilateral connections of the ventral premotor cortex in a new world primate
The present study describes the pattern of connections of the ventral premotor cortex (PMv) with various cortical regions of the ipsilateral hemisphere in adult squirrel monkeys. Particularly, we 1)Expand
Neuronal HIF-1α Protein and VEGFR-2 Immunoreactivity in Functionally Related Motor Areas following a Focal M1 Infarct
TLDR
While remote areas undergo a molecular response to the infarct, it is hypothesized that there is a delay in the initiation of the response, which ultimately may increase the ‘window of opportunity’ for neuroprotective interventions in the intact cortex. Expand
Enhancing the Alignment of the Preclinical and Clinical Stroke Recovery Research Pipeline: Consensus-Based Core Recommendations From the Stroke Recovery and Rehabilitation Roundtable Translational
TLDR
Guidelines are proposed for the pre-clinical modeling of stroke recovery and for the alignment of pre- clinical studies to clinical trials in stroke recovery. Expand
Error correction strategies for motor behavior after unilateral brain damage: short-term motor learning processes
TLDR
Results indicate that the deficits that individuals with stroke experience when adapting their movements to changed load conditions may be due to difficulty in rapidly integrating visual and proprioceptive information and deficits in executive function could also contribute to problems in producing accurate and consistent movements from trial to trial. Expand
Topographically divergent and convergent connectivity between premotor and primary motor cortex.
TLDR
It is found that PMv projections to M1 were not evenly distributed but rather were directed consistently to three domains within the rostro-lateral portion of M1. Expand
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