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Trypanosoma cruzi epimastigote endocytic pathway: cargo enters the cytostome and passes through an early endosomal network before storage in reservosomes.
- I. Porto-Carreiro, M. Attias, K. Miranda, W. de Souza, N. Cunha-E-Silva
- BiologyEuropean journal of cell biology
- 1 November 2000
It is proposed that the vesicular-tubular network is the early endosome of Trypanosoma cruzi epimastigotes, based on pH and protein uptake kinetics.
Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells
- Camila C. Santos, C. Sant'Anna, A. Terres, N. Cunha-E-Silva, J. Scharfstein, A. P. C. de A Lima
- BiologyJournal of Cell Science
- 1 March 2005
The studies suggest that chagasin regulates the endogenous activity of CP, thus indirectly modulating proteolytic functions that are essential for parasite differentiation and invasion of mammalian cells.
Electron microscopy and cytochemistry analysis of the endocytic pathway of pathogenic protozoa.
Evolutionary conservation of actin-binding proteins in Trypanosoma cruzi and unusual subcellular localization of the actin homologue
Protein sequence analysis and homology modelling revealed that the overall structure of T. cruzi actin is conserved and that the majority of amino-acid changes are concentrated on the monomer surface.
Heme requirement and intracellular trafficking in Trypanosoma cruzi epimastigotes.
All Trypanosoma cruzi developmental forms present lysosome-related organelles
- C. Sant'Anna, F. Parussini, D. Lourenço, W. Souza, J. Cazzulo, N. Cunha-E-Silva
- BiologyHistochemistry and Cell Biology
- 12 August 2008
It is demonstrated that trypomastigotes and amastigote forms also concentrate cruzipain, chagasin as well as serine carboxypeptidase in hydrolase-rich compartments of acidic nature and it is suggested that all T. cruzi developmental stages present lysosome-related organelles that in epimastsigotes have the additional and unique ability of storing cargo.
Glucose uptake in the mammalian stages of Trypanosoma cruzi.
Cryptic Paraflagellar Rod in Endosymbiont-Containing Kinetoplastid Protozoa
- C. Gadelha, B. Wickstead, W. de Souza, K. Gull, N. Cunha-E-Silva
- Biology, Environmental ScienceEukaryotic Cell
- 1 March 2005
A PFR1 gene is identified in the endosymbiont-bearing trypanosome Crithidia deanei and is able to partially complement a pfr1 null mutation in Leishmania mexicana cells, demonstrating that the encoded protein is functional.
Assembly of the Leishmania amazonensis flagellum during cell differentiation.
Improvement on the visualization of cytoskeletal structures of protozoan parasites using high-resolution field emission scanning electron microscopy (FESEM)
The results suggest that the observation of detergent extracted parasites using FESEM associated to backscattered analysis of immunolabeled specimens represents a new approach for the study of parasite cytoskeletal elements and their protein associations.