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The Genome Architecture of the Collaborative Cross Mouse Genetic Reference Population
TLDR
The Collaborative Cross Consortium reports here on the development of a unique genetic resource population, a multiparental recombinant inbred panel derived from eight laboratory mouse inbred strains, which shows that founder haplotypes are inherited at the expected frequency. Expand
Mechanisms of metastasis
TLDR
Some of the proposed models that were developed in attempt to understand the mechanisms of tumor dissemination and colonization as well as metastatic progression are summarized. Expand
Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer
TLDR
Findings imply that SIPA1 germline polymorphisms are associated with aggressive disease behavior in the cohort examined, and if these results hold true in other populations, knowledge of SipA1 SNP genotypes could potentially enhance current staging protocols. Expand
Metastasis Predictive Signature Profiles Pre-exist in Normal Tissues
TLDR
The results suggest that human metastasis-predictive gene expression signatures may be significantly driven by genetic background, rather than acquired somatic mutations, and suggest that predictive signature profiles could be developed from normal tissues in humans. Expand
Rrp1b, a New Candidate Susceptibility Gene for Breast Cancer Progression and Metastasis
TLDR
The data suggest that RRP1B may be a novel susceptibility gene for breast cancer progression and metastasis, and ECM gene expression was found to be consistently associated with Rrp1b expression. Expand
BRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane
TLDR
It is shown that BET inhibitors are effective against murine primary mammary tumors, but not pulmonary metastases, and differential biochemical and nuclear localization properties revealed in this study provide novel insights into the opposing roles of BRD4 isoforms in metastatic breast cancer progression. Expand
Differential MicroRNA expression tracks neoplastic progression in inflammatory bowel disease‐associated colorectal cancer
TLDR
Differential miRNA expression in IBD patients with associated CRC from non‐neoplastic tissue to dysplasia and eventually cancer and the role of dysregulated miRNAs in the TP53 pathway is identified and examined. Expand
Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion.
TLDR
These findings suggest that BRD4 may be altering the predisposition of tumors to undergo conversion to a more de-differentiated or primitive state during metastatic progression. Expand
Bromodomain 4 activation predicts breast cancer survival
TLDR
Microarray analysis of the mammary tumor cell lines identified a Brd4 activation signature that robustly predicted progression and/or survival in multiple human breast cancer datasets analyzed on different microarray platforms, and in vitro analysis shows that Brd 4 modulates extracellular matrix gene expression, a class of genes frequently present in metastasis-predictive gene signatures. Expand
Tumor markers and colorectal cancer: Utility in management
TLDR
This review will focus on markers that are currently used in the management of sporadic CRC and their limitations, as well as possible future clinical applications. Expand
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