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Finding the missing heritability of complex diseases
Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture.Expand
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The Genotype-Tissue Expression (GTEx) project
Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associatedExpand
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The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
Expression, genetic variation, and tissues Human genomes show extensive genetic variation across individuals, but we have only just started documenting the effects of this variation on the regulationExpand
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CONTEXT Influenza and respiratory syncytial virus (RSV) cause substantial morbidity and mortality. Statistical methods used to estimate deaths in the United States attributable to influenza have notExpand
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Allele-sharing models: LOD scores and accurate linkage tests.
  • A. Kong, N. Cox
  • Mathematics, Medicine
  • American journal of human genetics
  • 1 November 1997
Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation ofExpand
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Influenza-associated hospitalizations in the United States.
CONTEXT Respiratory viral infections are responsible for a large number of hospitalizations in the United States each year. OBJECTIVE To estimate annual influenza-associated hospitalizations in theExpand
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Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans
Generation of Swine Flu As the newly emerged influenza virus starts its journey to infect the world's human population, the genetic secrets of the 2009 outbreak of swine influenza A(H1N1) are beingExpand
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Obesity-associated variants within FTO form long-range functional connections with IRX3
Genome-wide association studies (GWAS) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes (T2D). Although the molecular mechanisms linkingExpand
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A gene-based association method for mapping traits using reference transcriptome data
Genome-wide association studies (GWAS) have identified thousands of variants robustly associated with complex traits. However, the biological mechanisms underlying these associations are, in general,Expand
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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in originExpand
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