Author pages are created from data sourced from our academic publisher partnerships and public sources.
Finding the missing heritability of complex diseases
Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture.… Expand
The Genotype-Tissue Expression (GTEx) project
Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated… Expand
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
Expression, genetic variation, and tissues Human genomes show extensive genetic variation across individuals, but we have only just started documenting the effects of this variation on the regulation… Expand
MORTALITY ASSOCIATED WITH INFLUENZA AND RESPIRATORY SYNCYTIAL VIRUS IN THE UNITED STATES
CONTEXT Influenza and respiratory syncytial virus (RSV) cause substantial morbidity and mortality. Statistical methods used to estimate deaths in the United States attributable to influenza have not… Expand
Allele-sharing models: LOD scores and accurate linkage tests.
Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation of… Expand
Influenza-associated hospitalizations in the United States.
CONTEXT Respiratory viral infections are responsible for a large number of hospitalizations in the United States each year. OBJECTIVE To estimate annual influenza-associated hospitalizations in the… Expand
Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans
Generation of Swine Flu As the newly emerged influenza virus starts its journey to infect the world's human population, the genetic secrets of the 2009 outbreak of swine influenza A(H1N1) are being… Expand
Obesity-associated variants within FTO form long-range functional connections with IRX3
Genome-wide association studies (GWAS) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes (T2D). Although the molecular mechanisms linking… Expand
A gene-based association method for mapping traits using reference transcriptome data
Genome-wide association studies (GWAS) have identified thousands of variants robustly associated with complex traits. However, the biological mechanisms underlying these associations are, in general,… Expand
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin… Expand