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Genomic Profiling of Messenger RNAs and MicroRNAs Reveals Potential Mechanisms of TWEAK-Induced Skeletal Muscle Wasting in Mice
Background Skeletal muscle wasting is a devastating complication of several physiological and pathophysiological conditions. Inflammatory cytokines play an important role in the loss of skeletal… Expand
The role of CaMKII in BDNF-mediated neuroprotection of retinal ganglion cells (RGC-5)
The purpose of the study is to determine if expression or secretion of brain-derived neurotrophic factor (BDNF) in retinal ganglion cells (RGC-5) is mediated by NFkappaB or Ca2+/calmodulin-dependent… Expand
Boundaries defined by adhesion molecules during development of the cerebral cortex: the J1/tenascin glycoprotein in the mouse somatosensory cortical barrel field.
The distribution of the 200/220 KDa J1 glycoprotein (J1-200/220), within the developing vibrissae-related barrel field of the mouse somatosensory cortex, was studied by immunocytochemistry using a… Expand
Developmental changes in the expression of NMDA receptor subunits (NR1, NR2A, NR2B) in the cat visual cortex and the effects of dark rearing.
The present study used Western blots to determine changes in the level of expression of the three major NMDA receptor subunits, NR1, NR2A, and NR2B, in relation to the 'critical period' in cat visual… Expand
Serum deprivation induces apoptotic cell death of transformed rat retinal ganglion cells via mitochondrial signaling pathways.
- I. Charles, A. Khalyfa, +4 authors N. Agarwal
- Biology, Medicine
- Investigative ophthalmology & visual science
- 1 April 2005
PURPOSE Apoptosis-related signaling pathways were investigated in a cultured rat retinal ganglion cell (RGC-5) line deprived of growth factors after serum withdrawal from the culture medium. … Expand
Early Involvement of Immune/Inflammatory Response Genes in Retinal Degeneration in DBA/2J Mice
- W. Fan, X. Li, W. Wang, J. Mo, H. Kaplan, N. Cooper
- Ophthalmology and eye diseases
- 11 March 2010
Purpose The DBA/2J (D2) mouse carries mutations in two of its genes, Tyrp1 and Gpnmb. These alterations result in the development of an immune response in the iris, leading to iris atrophy and… Expand
Comparative in Silico Analyses of Cpeb1–4 with Functional Predictions
Background Cytoplasmic polyadenylation element binding proteins (Cpebs) are a family of proteins that bind to defined groups of mRNAs and regulate their translation. While Cpebs were originally… Expand
Regulation of calcium/calmodulin-dependent protein kinase II in the adult rat retina is mediated by ionotropic glutamate receptors.
This study is concerned with the transmitter-mediated regulation of the alpha(50 kDa) and beta(60 kDa) subunits of calcium calmodulin dependent protein kinase II (CamKII) in the adult rat retina. The… Expand
Expression of two forms of glutamic acid decarboxylase (GAD67 and GAD65) during postnatal development of rat somatosensory barrel cortex
- P. J. Kiser, N. Cooper, G. Mower
- Biology, Medicine
- The Journal of comparative neurology
- 7 December 1998
The postnatal development of glutamic acid decarboxylase (GAD; GAD67 and GAD65) expression was studied in the rat somatosensory cortex. Delineation of barrels in layer IV by GAD67 immunoreactivity… Expand
Transcriptomic analysis of the zebrafish inner ear points to growth hormone mediated regeneration following acoustic trauma
- Julie B. Schuck, Huifang Sun, W. Penberthy, N. Cooper, X. Li, M. Smith
- Biology, Medicine
- BMC Neuroscience
- 2 September 2011
BackgroundUnlike mammals, teleost fishes are capable of regenerating sensory inner ear hair cells that have been lost following acoustic or ototoxic trauma. Previous work indicated that immediately… Expand