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Forward locomotion of the nematode C. elegans is achieved through modulation of a single gait
TLDR
A smooth transition from swimming to crawling is revealed, marked by a linear relationship between key locomotion metrics, and it is shown that environmental forces play only a small role in determining the shape of the worm, placing conditions on the minimal pattern of internal forces driving locomotion.
Neural control of Caenorhabditis elegans forward locomotion: the role of sensory feedback
TLDR
A simple yet biologically-grounded model for the neural control of Caenorhabditis elegans forward locomotion finds that a minimal circuit of AVB interneurons and B-class motoneurons is sufficient to generate and sustain fictiveforward locomotion patterns that are robust to significant environmental perturbations.
Gait Modulation in C. elegans: An Integrated Neuromechanical Model
TLDR
A model of C. elegans forward locomotion is presented that includes a neuromuscular control system that relies on a sensory feedback mechanism to generate undulations and is integrated with a physical model of the body and environment and reproduces the entire swim-crawl transition with no modulatory mechanism.
Long term behavior of lithographically prepared in vitro neuronal networks.
TLDR
It is suggested that different-size networks self-organize to adjust their activities over many time scales, as predictions of current models differ from the observations.
Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans
TLDR
A specific interneuron is identified that controls this decision via top-down extrasynaptic aminergic potentiation of the primary osmosensory neurons to increase their sensitivity to the barrier and it is established that food deprivation increases the worm's willingness to cross the dangerous barrier by suppressing this pathway.
GC composition of the human genome: in search of isochores.
TLDR
This paper addresses the question of the validity of the isochore theory through a rigorous sequence-based analysis of the human genome and finds that a four-family model of putative isochores is the most parsimonious multi-Gaussian model that can be fitted to the empirical data.
Swimming at low Reynolds number: a beginners guide to undulatory locomotion
Undulatory locomotion is a means of self-propulsion that relies on the generation and propagation of waves along a body. As a mode of locomotion it is primitive and relatively simple, yet can be
Immune response and virus population composition: HIV as a case study
TLDR
A new model of intrahost virus dynamics is presented, which takes into account the relationship between virus replication rate and the level of antigen displayed by infected cells, and shows how the cell–directed immune response controls both virus load and virus replication rates.
Volumetric reconstruction of main Caenorhabditis elegans neuropil at two different time points
TLDR
It is conjecture that a spatially constrained, genetic model could provide sufficient synaptic specificity, and it is shown that additional specificity, such as sub-cellular domains or alternative splicing, would be required to reproduce the wiring specificity in the nerve ring.
Fluctuations, pauses, and backtracking in DNA transcription.
TLDR
A molecular multistep model of transcription elongation is presented that demonstrates that transcription times are in general non-Poisson-distributed and model transcriptional pauses due to backtracking of the RNA polymerase as a first passage process suggest that transcriptional pause may be a significant contributor to the variability in transcription rates.
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