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Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue.
It is found that human MAdCAM-1, as in the mouse, is expressed in a tissue-selective manner and may be a relevant tissue-specific therapeutic target for the modulation of inflammatory bowel disease activity. Expand
Stage‐specific embryonic antigens (SSEA‐3 and ‐4) are epitopes of a unique globo‐series ganglioside isolated from human teratocarcinoma cells.
Two monoclonal antibodies (MC631 and MC813‐70) raised against 4‐ to 8‐cell stage mouse embryos and a human teratocarcinoma cell line, respectively, detect the stage‐specific embryonic antigens, theExpand
Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1.
A MIDAS-like domain serves a critical role in beta 7 integrin-mediated adhesion in mucosal immunity and is found within the region of beta 7 that specifies MAdCAM-1 binding. Expand
Novel Fucolipids Accumulating in Human Adenocarcinoma
A series of glycolipids having the X determinant (Gal~1+4[Fuccr1+3]GlcNAc) at the terminus and a fucosyl a143 residue at the internal GlcNAc residue have been isolated and characterized from tumorExpand
Mutational analysis of MAdCAM-1/alpha4beta7 interactions reveals significant binding determinants in both the first and second immunuglobulin domains.
It is found that, in addition to critical CD loop residues, other regions in both domain one and two contribute to MAdCAM-1/alpha4beta7 interactions, including a buried arginine residue in the F strand ofdomain one and several acidic residues in a highly extended DE ribbon in domain 2. Expand
Novel fucolipids accumulating in human adenocarcinoma. II. Selective isolation of hybridoma antibodies that differentially recognize mono-, di-, and trifucosylated type 2 chain.
Two monoclonal antibodies, FH2 and FH3, do not discriminate among various glycolipids having fucosylated type 2 chain, and their reactivities are essentially similar to previously established antibodies directed to the X determinant. Expand
Mutational analysis of MAdCAM-1/α4β7 interactions reveals significant binding determinants in both the first and second immunoglobulin domains
This work describes the use of chimeric MAdCAM-1/VCAM- 1 receptors and point mutations in M adhesion molecules to define other sites that are required for binding to the integrin α4β7. Expand
Factors affecting expression of glycolipid tumor antigens: influence of ceramide composition and coexisting glycolipid on the antigenicity of gangliotriaosylceramide in murine lymphoma cells.
Three factors, i.e., ceramide composition, coexisting glycolipids, and an antibody-dependent gly colipid change, are therefore important in determination of glycolipsid antigenicity and antigen modulation by antibodies. Expand
Enzymatic and organizational difference in expression of a Burkitt lymphoma-associated antigen (globotriaosylceramide) in Burkitt lymphoma and lymphoblastoid cell lines.
The expression in Burkitt and non-Burkitt lymphoma is dependent on Gb3 synthesis due to alpha-galactosyltransferase activity and (ii) membrane organization of Gb2, which may be controlled through interaction with the sialosyl residue of a second glycoconjugate at the cell surface. Expand
Novel modified tripeptide inhibitors of α4β7 mediated lymphoid cell adhesion to MAdCAM-1
MAdCAM-1 specifically binds the lymphocyte integrin α4β7 and participates in the homing of leukocytes to intestinal mucosal sites. The LDT sequence located on the CD loop of MAdCAM-1 is an importantExpand