Skip to search formSkip to main contentSkip to account menu
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate
TLDR
FkbO, RapK, Hyg5, and Bra8 are founder members of a previously unrecognized family of enzymes acting on chorismate, which includes the product of the bra8 gene from the pathway to the terpenoid natural product brasilicardin.
View on Publisher
Roles of rapH and rapG in Positive Regulation of Rapamycin Biosynthesis in Streptomyces hygroscopicus
TLDR
Based on DNA sequence analysis, the products of genes rapH and rapG showed high similarities with two different families of transcriptional activators, LAL and AraC, respectively, and indicated an essential role of the RapG regulator for rapamycin biosynthesis and a supportive role of RapH.
View on ASMUSA
SB-202742, a novel beta-lactamase inhibitor isolated from Spondias mombin.
SB-202742 [1], an anacardic acid derivative possessing beta-lactamase inhibitory activity, has been isolated from a hexane extract of the plant, Spondias mombin. Its isolation, structure…
View on PubMed
Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection
TLDR
Initial results of the optimisation program which led to identification of the sangamides, compounds that exhibit significantly improved potential for the treatment of chronic HCV infection are reported.
View via Publisher
Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family
TLDR
These data demonstrate that naturally occurring sanglifehrins are suitable lead compounds for the development of novel analogues that are less immunosuppressive and that have improved metabolism and pharmacokinetic properties.
View on ASMUSA
SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. I. Fermentation, isolation and properties.
A novel, potent and selective inhibitor of bacterial tyrosyl tRNA synthetase, designated SB-219383 has been isolated from Micromonospora sp. NCIMB 40684. The fermentation, isolation and some…
View on PubMed
SB-204900, a novel oxirane carboxamide from Clausena lansium
SB-204900 (1), a novel oxirane carboxamide, has been isolated from a hexane extract of the fruit tree Clausena lansium (Rutaceae). The structure of 1 was determined by detailed spectroscopic methods…
View via Publisher
Recombinant strains for the enhanced production of bioengineered rapalogs.
View on PubMed
Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.
TLDR
A biosynthetic medicinal chemistry approach was applied to the optimization of the natural product Hsp90 inhibitor macbecin, resulting in a nonquinone compound (5) that has significantly improved binding affinity to HSp90 and reduced toxicity.
View on PubMed
Bioengineering and Semisynthesis of an Optimized Cyclophilin Inhibitor for Treatment of Chronic Viral Infection
View on Elsevier
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License