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The mechanism of action of cyclosporin A and FK506.
The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin suppress the immune response by inhibiting evolutionary conserved signal transduction pathways. CsA, FK506, and rapamycin bind toExpand
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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
THE immunosuppressive drugs cyclosporin A (CsA) and FKS06 both interfere with a Ca2+-sensitive T-cell signal transduction pathway1–4thereby preventing the activation of specific transcription factorsExpand
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Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.
The NF-AT family of transcription factors participates in the regulation of early immune response genes such as IL-2, IL-4, CD40 ligand, and Fas ligand in response to Ca2+/calcineurin signalsExpand
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Signal transmission between the plasma membrane and nucleus of T lymphocytes.
INITIATING THE GENETIC PROGRAM LEADING TO T CELL ACTIVATION 1057 Integration of the Diverse Signals Required for T Cell Activation on the Regulatory Regions of Early Genes ..... .. . .. . .. . . ...Expand
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Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
CELLS need to distinguish between transient Ca2+ signals that induce events such as muscle contraction, secretion, adhesion and synaptic transmission, and sustained Ca2+ signals that are involved inExpand
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Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization*
The subcellular localization of the transcription factor NFATc is tightly regulated by the calcium-regulated phosphatase calcineurin, which acts to directly dephosphorylate NFATc, causing its rapidExpand
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The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells*
Although best known for its role in T lymphocyte activation, the calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway is also known to be involved in a wide range of otherExpand
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Glycogen Synthase Kinase-3 Inhibits the DNA Binding Activity of NFATc*
The NFAT family of transcription factors is required for the expression of numerous immunologically important genes and plays a pivotal role in both the initiation and coordination of the immuneExpand
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A Constitutively Active NFATc1 Mutant Induces a Transformed Phenotype in 3T3-L1 Fibroblasts*
The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway is best known for its role in T lymphocyte activation. However, it has become increasingly apparent that this signalingExpand
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Calcineurin Mediates the Calcium-dependent Inhibition of Adipocyte Differentiation in 3T3-L1 Cells*
Recent studies have revealed that the calcium-dependent serine/threonine phosphatase calcineurin mediates the effects of intracellular calcium in many different cell types. In this study weExpand
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