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Pharmacokinetics and Oral Bioavailability of Scopolamine in Normal Subjects
The pharmacokinetics and bioavailability of scopolamine were evaluated in six healthy male subjects receiving 0.4 mg of the drug by either oral or intravenous administration. Plasma and urine samplesExpand
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Changes in sympathoadrenal response to standing in humans after spaceflight.
Plasma catecholamine levels and cardiovascular responses to standing were determined in astronauts before and after several Space Shuttle missions. Blood pressure, heart rate, and cardiac output wereExpand
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Alteration in human mononuclear leucocytes following space flight.
Reduced in vitro mitogen-stimulated proliferative responses have routinely been observed from astronauts' mononuclear leucocytes following space flight. This study investigated the effect of spaceExpand
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Metabolic changes observed in astronauts.
Study of metabolic alterations that occur during space flight can provide insight into mechanisms of physiologic regulation. Results of medical experiments with astronauts reveal rapid loss of volumeExpand
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Genetic mapping of xthA, the structural gene for exonuclease III in Escherichia coli K-12.
The genes xthA, pncA, and pabB were ordered relative to others by two- and three-factor transductional crosses with bacteriophage P1. The genes studied span 2 min (2%) of the genetic map ofExpand
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Bioavailability of intranasal scopolamine in normal subjects.
The bioavailability of scopolamine in three dosage forms was compared in 12 healthy nonsmoking male volunteers. Subjects received 0.4-mg doses of scopolamine bromide in intravenous (i.v.), intranasalExpand
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Dexamethasone effects on creatine kinase activity and insulin-like growth factor receptors in cultured muscle cells.
We examined the effects of dexamethasone on creatine kinase (CK) activity and insulin-like growth factor I (IGF-I) binding in two skeletal muscle-derived cell lines (mouse, C2C12; rat, L6) and in oneExpand
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Insulin-like growth factor-I binds selectively to human peripheral blood monocytes and B-lymphocytes.
Insulin-like growth factor-I (IGF-I) is a potential modulator of responses to a variety of immunological challenges. Previous studies have suggested that specific IGF-I receptors are present onExpand
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Alterations in renal stone risk factors after space flight.
Exposure to the microgravity environment of space produces a number of physiological changes of metabolic and environmental origin that could increase the potential for renal stone formation.Expand
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Long-term storage of salivary cortisol samples at room temperature.
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