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Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria
  • N. Chin, H. Neu
  • Biology, Medicine
    Antimicrobial Agents and Chemotherapy
  • 1 March 1984
TLDR
Ciprofloxacin was 4- to 32-fold more active than norfloxACin and inhibited gentamicin-, ameikacin-, cefotaxime-, and moxalactam-resistant members of the family Enterobacteriaceae and P. aeruginosa and methicillin-resistant Staphylococcus aureus.
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Multicenter evaluation of proposed standardized procedure for antifungal susceptibility testing of filamentous fungi
TLDR
The overall optimal testing conditions identified were determination of colorimetric MICs after 48 to 72 h of incubation with an inoculum density of approximately 10(4) CFU/ml, proposed as guidelines for a reference broth microdilution method.
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In vitro activity of fluvastatin, a cholesterol-lowering agent, and synergy with flucanazole and itraconazole against Candida species and Cryptococcus neoformans
TLDR
Fluvastatin, a cholesterol-lowering drug, exhibited minimal activity against Candida species and Cryptococcus neoformans, and was combined with fluconazole or itraconazole to achieve combined fungicidal activity.
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In vitro activity of sparfloxacin
TLDR
Sparfloxacin, a new fluoroquinolone, inhibited the majority of members of the family Enterobacteriaceae at less than or equal to 1 microgram/ml and against Pseudomonas aeruginosa, it was less active than ciprofl oxacin but twofold more active than ofloxacIn.
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In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim
  • N. Chin, H. Neu
  • Biology, Medicine
    Antimicrobial Agents and Chemotherapy
  • 1 November 1983
TLDR
Enoxacin inhibited organisms resistant to cefotaxime, moxalactam, gentamicin, and piperacillin, but serum did not decrease minimal inhibitory concentrations or minimal bactericidal concentrations, and resistance frequency development was less than 10(-9) for most bacterial species.
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In vitro activity of Ro 23-6240, a new fluorinated 4-quinolone
The in vitro activity of Ro 23-6240 (AM833), 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-7(4-methyl-1-piper azinyl) quinolone-3-carboxylic acid, was compared with those of norfloxacin, enoxacin,…
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In vitro activity of E-1040, a novel cephalosporin with potent activity against Pseudomonas aeruginosa
TLDR
E-1040 inhibited imipenem-, piperacillin-, aztreonam-, and tobramycin-resistant P. aeruginosa species and inhibited other Pseudomonas species that were resistant to ceftazidime, but had poor affinity for these enzymes.
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In vitro activity and beta-lactamase stability of two oral cephalosporins, ceftetrame (Ro 19-5247) and cefetamet (Ro 15-8074)
TLDR
Two new orally administered aminothiazolyl imimomethoxy cephalosporins inhibited hemolytic streptococci and Streptococcus pneumoniae but were less active against staphylococci than were cephalexin and cefaclor, and a marked inoculum effect was noted for Enterobacteriaceae carrying the Richmond-Sykes type 1A chromosomally mediated beta-lactamases.
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In vitro activity of an oral iminomethoxy aminothiazolyl cephalosporin, R-3746
  • N. Chin, H. Neu
  • Biology, Medicine
    Antimicrobial Agents and Chemotherapy
  • 1 May 1988
TLDR
In vitro activity of R-3746, an iminomethoxy aminothiazolyl cephalosporin with a CH2OCH3 moiety at position 3, was compared with those of other antibiotics and was markedly superior to cefaclor, cephalexin, amoxicillin-clavulanate, and trimethoprimsulfamethoxazole.
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In vitro activity of cefquinome, a new cephalosporin, compared with other cephalosporin antibiotics.
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