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The cell biology of taste
Taste buds are aggregates of 50–100 polarized neuroepithelial cells that detect nutrients and other compounds. Combined analyses of gene expression and cellular function reveal an elegant cellularExpand
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The role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds
ATP has been shown to be a taste bud afferent transmitter, but the cells responsible for, and the mechanism of, its release have not been identified. Using CHO cells expressing high-affinityExpand
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Separate Populations of Receptor Cells and Presynaptic Cells in Mouse Taste Buds
Taste buds are aggregates of 50–100 cells, only a fraction of which express genes for taste receptors and intracellular signaling proteins. We combined functional calcium imaging with single-cellExpand
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Breadth of Tuning and Taste Coding in Mammalian Taste Buds
A longstanding question in taste research concerns taste coding and, in particular, how broadly are individual taste bud cells tuned to taste qualities (sweet, bitter, umami, salty, and sour). TasteExpand
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CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes
Recognition of sweet, bitter and umami tastes requires the non-vesicular release from taste bud cells of ATP, which acts as a neurotransmitter to activate afferent neural gustatory pathways. However,Expand
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A metabotropic glutamate receptor variant functions as a taste receptor
Sensory transduction for many taste stimuli such as sugars, some bitter compounds and amino acids is thought to be mediated via G protein-coupled receptors (GPCRs), although no such receptors thatExpand
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Functional Cell Types in Taste Buds Have Distinct Longevities
Taste buds are clusters of polarized sensory cells embedded in stratified oral epithelium. In adult mammals, taste buds turn over continuously and are replenished through the birth of new cells inExpand
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The Taste of Monosodium Glutamate: Membrane Receptors in Taste Buds
Receptor proteins for photoreception have been studied for several decades. More recently, putative receptors for olfaction have been isolated and characterized. In contrast, no receptors for tasteExpand
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An Optimized Method for In Situ Hybridization with Signal Amplification That Allows the Detection of Rare mRNAs
In situ hybridization (ISH) using nonradioactive probes enables mRNAs to be detected with improved cell resolution but compromised sensitivity compared to ISH with radiolabeled probes. To detect rareExpand
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Knocking Out P2X Receptors Reduces Transmitter Secretion in Taste Buds
In response to gustatory stimulation, taste bud cells release a transmitter, ATP, that activates P2X2 and P2X3 receptors on gustatory afferent fibers. Taste behavior and gustatory neural responsesExpand
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