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Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity
TLDR
The conservation of the primary structure of 26 RFa during vertebrate evolution, the discrete localization of the mRNA encoding its precursor in hypothalamic nuclei involved in the control of feeding behavior, and the observation that 26RFa possesses orexigenic properties indicate that this neuropeptide may play important biological functions. Expand
Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake"
TLDR
It is found that I125-obestatin does not bind GPR39 and observed no effects of obestatin on G PR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilization, and GPR 39 internalization). Expand
Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release.
TLDR
Data demonstrate that apelin acts as a potent diuretic neuropeptide counteracting AVP actions through inhibition of AVP neuron activity and AVP release, indicating that AVP and apelin are conversely regulated to facilitate systemic AVPrelease and suppress diuresis. Expand
Isolation, characterization, and distribution of a novel neuropeptide, Rana RFamide (R‐RFa), in the brain of the European green frog Rana esculenta
TLDR
The occurrence of this novel neuropeptide in the hypothalamus and median eminence and in the dorsal region of the spinal cord suggests that, in frog, R‐RFa may exert neuroendocrine activities and/or may be involved in the transmission of nociceptive stimuli. Expand
Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord
TLDR
The distribution of 26RF‐LI suggests that 26RFa and/or 43RFa may modulate feeding, sexual behavior and transmission of nociceptive stimuli. Expand
Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat
TLDR
The present report provides the first detailed mapping of 26RFa binding sites and GPR103 mRNA in the rat central nervous system (CNS), and suggests that 26 RFa has multiple functions in the CNS that are mediated by at least two distinct receptors. Expand
Immunohistochemical localization and biochemical characterization of hypocretin/orexin‐related peptides in the central nervous system of the frog Rana ridibunda
TLDR
The occurrence of hCrt‐containing cell bodies in the hypothalamus and the widespread distribution of hcrt‐immunoreactive fibers throughout the brain and spinal cord suggest that, in amphibians, hcrts may exert neuroendocrine, neurotransmitter, and/or neuromodulator activities. Expand
Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α-MSH release.
TLDR
The hypothesis that central apelin is involved in regulating body weight and feeding behavior through the direct stimulation of α-MSH release is supported. Expand
The orexigenic activity of the hypothalamic neuropeptide 26RFa is mediated by the neuropeptide Y and proopiomelanocortin neurons of the arcuate nucleus.
TLDR
The present data demonstrate for the first time that 26RFa exerts its orexigenic activity by stimulating the release of NPY in the Arc, which in turn inhibits POMC neurons by activating the Y1 and Y5 receptors. Expand
The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions
TLDR
Evidence that the 26RFa/GPR103 system regulates steroidogenesis, bone formation, nociceptive transmission and arterial blood pressure has also been reported, suggesting that this RFamide peptide appears to act as a key neuropeptide in vertebrates controlling vital neuroendocrine functions. Expand
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