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Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms
Ras activation is a frequent event in human hepatocarcinoma that may contribute to resistance towards apoptosis. Salirasib is a ras and mTOR inhibitor that induces a pro-apoptotic phenotype in humanExpand
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  • Open Access
Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition
BackgroundDysregulation of epidermal growth factor and insulin-like growth factor signaling play important roles in human hepatocellular carcinoma (HCC), leading to frequent activation of theirExpand
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Ras inhibition in hepatocarcinoma by S‐trans‐trans‐farnesylthiosalicyclic acid: Association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis
Activation of Ras and its downstream signaling pathways, likely contribute to the development of hepatocarcinoma. We have previously shown that intraperitoneal injections of the Ras inhibitorExpand
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Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: a rationale for combination with radiation therapy.
BACKGROUND AND PURPOSE The relevance of Mitogen Activated Protein Kinase (MAPK) inhibitors as co-treatments for radiation therapy is investigated, with special focus on a potential link between theExpand
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  • Open Access
The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats.
BACKGROUND Aberrant activation of oncogenes, such as Ras, likely contributes to the development of hepatocarcinoma (HCC). AIMS/METHODS We evaluated in vivo the effect of intraperitoneal injectionsExpand
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Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma
BackgroundThe increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field. Therefore, a vast need of experimentalExpand
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  • Open Access
Je suis tombée
The effect of S-farnesyl-thiosalicylic acid (FTS, salirasib) on proliferation, apoptosis and signalling pathways in human hepatocarcinoma cell lines
Hepatocarcinoma is a frequent and lethal cancer with limited treatment options at an advanced stage. Ras activation seems to be a constant and early event in human hepatocarcinogenesis. Previous workExpand