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Adopting a Patient-Centered Approach to Primary Outcome Analysis of Acute Stroke Trials Using a Utility-Weighted Modified Rankin Scale
TLDR
A utility-weighted mRS performs similar to the standard ordinal mRS in detecting treatment effects in actual stroke trials and ensures the quantitative outcome is a valid reflection of patient-centered benefits.
Standardized Nomenclature for Modified Rankin Scale Global Disability Outcomes
TLDR
This statement advances recommended rubrics, developed by the Stroke Therapy Academic Industry Roundtable collaboration using an iterative, mixed-methods process, to enable the modified Rankin Scale to meet robust contemporary scale standards.
A randomized controlled study of intravenous fluid in acute ischemic stroke
A Utility-Weighted Modified Rankin Scale: Derivation and Application to Completed Stroke Trials (P5.008)
TLDR
A utility-weighted mRS performs similarly to the standard ordinal mRS in detecting treatment effects in actual stroke trials and in ensures the quantitative outcome is a valid reflection of patient-centered benefits.
The association between risk factors for ischemic stroke and microalbuminuria.
TLDR
Diabetes mellitus and hypertension are significantly risk factor of ischemic stroke related to microalbuminuria, and the common risk factors were hypertension, dyslipidemia and multiple cerebral infarction.
Abstract 138: Assessing Disability Outcome in Acute Stroke Clinical Trials: Increased Study Power with Linear (ALDS) Compared with Ordinal (mRS) Scales
TLDR
Consecutive patients undergoing 3 month final outcome visits in the NIH FAST-MAG phase 3 trial were assessed with the modified Rankin Scale and the Academic Medical Center linear disability scale, finding that the mRS lacks granularity and is ordinal, constraining study power.
Abstract T MP92: Patient Valuation of Each Level of the Modified Rankin Global Disability Scale: Insights from the Stroke Impact Scale
TLDR
Mild scores on the modified Rankin Scale are particularly associated with quality of life deficits in the domains of strength, emotion, activities of daily living, and social participation, while more severe mRS abnormalities compromise QOL across all domains of functioning.
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