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A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a strong genetic predisposition. A locus at human chromosome 10q26 affectsExpand
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A candidate prostate cancer susceptibility gene at chromosome 17p
It is difficult to identify genes that predispose to prostate cancer due to late age at diagnosis, presence of phenocopies within high-risk pedigrees and genetic complexity. A genome-wide scan ofExpand
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Predisposition locus for major depression at chromosome 12q22-12q23.2.
Major depression disorder is a common psychiatric disease with a major economic impact on society. In many cases, no effective treatment is available. The etiology of major depression is complex, butExpand
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Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32Expand
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Genome‐wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early‐onset major depression and anxiety disorders
Major depressive disorder (MDD) is a common, clinically heterogeneous disorder often found comorbid with other disorders. We studied recurrent, early‐onset MDD (MDD‐RE) and anxiety disorders inExpand
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PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size
We present a general approach to perform association analyses in pedigrees of arbitrary size and structure, which also allows for a mixture of pedigree members and independent individuals to be analyzed together, to test genetic markers and qualitative or quantitative traits. Expand
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Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease.
BACKGROUND Cytokine gene variations are contributory factors in inflammatory pathology. Allele frequencies of interleukin (IL)-1 cluster genes [IL-1A(-889), IL-1B(-511), IL-1B(+3953), IL-1RN Intron 2Expand
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Classification tree analysis: a statistical tool to investigate risk factor interactions with an example for colon cancer (United States)
Objective: Classification tree analysis is a potentially powerful tool for investigating multilevel interactions. Within the context of colon cancer etiology it may help identify disease pathways andExpand
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An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers.
In population- and family-based association studies, it is useful to have some knowledge of the patterns of linkage disequilibrium that exist between markers in candidate regions. When such studiesExpand
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An interleukin-1 genotype is associated with fatal outcome of meningococcal disease.
To determine whether known variants of the interleukin-1 (IL-1) and tumor necrosis factor (TNF) gene families are associated with severe manifestations of meningococcal disease, 276 white patientsExpand
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