N. C. O'Sullivan

Publications23
h-index12
Citations417
Highly Influential Citations18
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CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity
Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular,… Expand
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Notch signalling becomes transiently attenuated during long-term memory consolidation in adult Wistar rats
Recent evidence has suggested a role for Notch in memory consolidation but the means by which this evolutionarily conserved mechanism serves these plasticity-related processes remains to be… Expand
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Hippocampal region-specific regulation of NF-κB may contribute to learning-associated synaptic reorganisation
Activity of the transcription factor NF-kappaB is required for memory formation, but the identity and function of the genes it may regulate in this context remain obscure. Here, we comprehensively… Expand
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Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer
Background:Insulin-like growth factor 1 (IGF1) promotes breast cancer and disease progression. Bioavailability of IGF1 is modulated by IGF-binding proteins (IGFBPs). IGFBP4 inhibits IGF1 activity but… Expand
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Reticulon-like-1, the Drosophila orthologue of the Hereditary Spastic Paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons
Several causative genes for hereditary spastic paraplegia encode proteins with intramembrane hairpin loops that contribute to the curvature of the endoplasmic reticulum (ER), but the relevance of… Expand
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Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning
A learning event initiates a cascade of altered gene expression leading to synaptic remodelling within the hippocampal dentate gyrus, a structure vital to memory formation. To illuminate this… Expand
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Mkl transcription cofactors regulate structural plasticity in hippocampal neurons.
Expressed throughout the central nervous system, the myocardin-related, megakaryoblastic acute leukemia 1 and 2 (Mkl1/2) are transcriptional cofactors that can be found tethered in the cytoplasm to… Expand
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Temporal proteomic profile of memory consolidation in the rat hippocampal dentate gyrus
Information storage in the brain depends on the ability of neurons to alter synaptic connectivity within key circuitries such as the hippocampus. Memory‐associated synaptic plasticity is mediated by… Expand
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ER-shaping proteins are required for ER and mitochondrial network organization in motor neurons.
Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders characterized by degeneration of the longest motor neurons in the corticospinal tract, leading to muscle weakness and… Expand
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Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat
A range of adverse, early life environmental influences such as viral infection and social deprivation are thought to increase risk of psychiatric illness later in life. Here, we used peripheral… Expand
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