N. Busch

Publications30
h-index2
Citations15
Highly Influential Citations0
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Biotransformation study of para-substituted phenylpiperazines in beagle dogs by gas chromatography-mass spectrometry.
TLDR
Beagle dogs were treated orally with para-chloro-, para-fluoro- and para-methyl-phenylpiperazine derivatives, and urine was collected for 72 h after treatment and two kinds of hydroxylated metabolites were found.
N-dephenylation of CERM 3517 (mociprazine) in beagle dogs. A mass spectrometric determination.
CERM 3517 (mociprazine), a new antiemetic compound, was administered orally at 10 mg/kg twice a day for 4 days to six Beagle dogs in order to identify the major metabolite. Mass spectrometric…
Comparative study of the biotransformation of bepridil analogs in isolated liver cells from one rat. Relationships between structure and in vitro liver toxicity
TLDR
The biotransformation of several analogs of the anti-calcium agent bepridil was studied comparatively in liver cells isolated from one rat, finding thatortho-substituted analogs were more toxic thanpara- ormeta-subStituted ones.
A process for preparing novel substituted piperazines
N-Dephenylated and N-phenyl urinary metabolites of mociprazine (CERM 3517) in beagle dogs after oral administration. A mass spectrometric determination
TLDR
The role of the para-hydroxyl intermediate was proved to be essential for the N-dephenylation after intravenous administration of meta- and para-Hydroxylated derivatives of CERM 3517 to five beagle dogs.
.alpha.-QUINUCLIDYLMETHYL PHENYL KETONES
Process for the production of new amine compounds as well as their addition salts and quaternary ammonium salts for pharmaceutical use
3-isobutoxy-2-pyrrolidino-N-phenyl-n-benzylpropylamin, process for its preparation and pharmaceutical compositions containing them
A method for obtaining tetrahydro-1, 4-oxazines in 2, 4 and 2, 2, 4
Benzoxazolinones and process for production thereof
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