• Publications
  • Influence
Relative toxicity of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antidepressants.
TLDR
Venlafaxine and dothiepin are pro-convulsant in overdose, but less likely to cause coma than TCAs and SSRIs, and Antidepressants other thanTCAs or venlafxine should be considered in patients at risk of seizure or suicide. Expand
Guidelines for the management of paracetamol poisoning in Australia and New Zealand — explanation and elaboration
TLDR
Revised guidelines have been developed by a panel of clinical toxicologists consulting to the poisons information centres in Australia and New Zealand using a workshop and consultative process to reconcile management advice with current Australasian clinical toxicology practice. Expand
Delayed Psychological Morbidity Associated with Snakebite Envenoming
TLDR
Snakebite causes significant ongoing psychological morbidity, a complication not previously documented, and the economic and social impacts of this problem need further investigation. Expand
Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortality data
TLDR
The relative frequency with which venlafaxine and other new antidepressants result in fatal poisoning is established, to establish the relative frequency of the use of newer serotoninergic antidepressants. Expand
A model for the management of self‐poisoning
To describe the development and activity of a multidisciplinary service to manage self‐poisoning.
Cardiovascular Adverse Effects of Antipsychotic Drugs
TLDR
Incomplete evidence suggests that arrhythmias and sudden death are a particular problem with certain drugs, high risk populations or people taking interacting drugs (such as drugs that prolong the QT interval, e.g. tricyclic antidepressants, drugs that inhibit antipsychotic drug metabolism, or diuretics). Expand
Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning?
TLDR
A shorter hospital stay, patient and doctor convenience, and the concerns over the reduction in bioavailability of oral N- acetylcysteine by charcoal and vomiting make intravenous N-acetylcy Steine preferable for most patients with acetaminophen poisoning. Expand
The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine.
TLDR
This study confirmed that early treatment with N -acetylcysteine (within 8 hours of ingestion) is more effective than later treatment and demonstrated a reduction of drug-related adverse outcomes with the 60-minute infusion. Expand
The Spectrum of Intermediate Syndrome Following Acute Organophosphate Poisoning: A Prospective Cohort Study from Sri Lanka
TLDR
Characteristic changes in RNS, preceding the development of IMS, help to identify a subgroup of patients at high risk of developing respiratory failure and indicates that IMS is a spectrum disorder. Expand
Oximes for acute organophosphate pesticide poisoning.
TLDR
Current evidence is insufficient to indicate whether oximes are harmful or beneficial in the management of acute organophosphorus pesticide poisoning, and a large RCT is required to compare the World Health Organization recommended pralidoxime regimen with placebo. Expand
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