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A prospective evaluation of a simplified captopril test for the detection of renovascular hypertension.
TLDR
A single postcaptopril plasma renin activity value of 5.7 ngAl.mL-1.h-1 or greater is a simplified screening test for renovascular hypertension, with excellent sensitivity and acceptable specificity. Expand
Corticotrophin-releasing hormone and platelet-activating factor induce transcription of the type-2 cyclo-oxygenase gene in human fetal membranes.
TLDR
Data indicate that the increased fetal membrane prostaglandin production in response to CRH or PAF may involve the induction of COX-2, and reverse transcription-polymerase chain reaction analyses showed that CRH and PAF increased the transcription of COx-2 mRNA two-fold after 8 h culture. Expand
Interleukin-1beta and bacterial endotoxin change the metabolism of prostaglandins E2 and F2alpha in intact term fetal membranes.
TLDR
It is concluded that IL-1beta and LPS moderately decrease the metabolism of prostaglandins, which may contribute to increasing the local levels of active prostaglandsins induced by these stimuli. Expand
Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones.
TLDR
Human rIL-3 expressed in COS7 cells has multipotential CSF activity in semisolid cultures of bone marrow cells, and selectively induced the proliferation of My-10+ marrow or cord blood cells in liquid cultures. Expand
IL‐1β and IL‐8 in Human Fetal Membranes: Changes with Gestational Age, Labor, and Culture Conditions
TLDR
Increasing expression of IL‐1β and IL‐8 in amnion and choriodecidua in the third trimester and after labor supports a role for these cytokines in the establishment of labor. Expand
A spontaneous induction of fetal membrane prostaglandin production precedes clinical labour.
TLDR
The high basal production of PGE2 was attributed to prior in vivo activation of the membranes such that PGE1 synthesis could not be further stimulated in vitro, and the maximum levels of P GE2 were similar in all experiments, and were independent of the stimulus used. Expand
Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein in human fetal membranes throughout pregnancy and at term.
TLDR
Results are consistent with a role for 5-LOX and FLAP in the control of parturition at term, and suggest an involvement earlier in pregnancy. Expand
The effects of a cytokine suppressive anti-inflammatory drug on the output of prostaglandin E(2) and interleukin-1 beta from human fetal membranes.
TLDR
Investigation of the effects of a cytokine-suppressant anti-inflammatory drug on the output of prostaglandin E(2) (PGE(2)) and interleukin (IL)-1 beta from human fetal membranes in vitro indicates that they are of possible use in premature labour. Expand
Pre- and postjunctional actions of hydralazine in vascular and nonvascular smooth muscle in vitro.
TLDR
The results from the rabbit ear artery confirm that in some vessels the presence of sympathetic nerve terminals can modify the postjunctional actions of low concentrations of hydralazine, however, the other vascular tissue studied (rat renal vascular bed) was sensitive toLow concentrations of Hydralazine while innervated. Expand
Differential effects of oral trandolapril and enalapril on rat tissue angiotensin-converting enzyme.
TLDR
Differences between trandolapril and enalapril in CE inhibition observed in heart ventricle, adrenal cortex and medulla could be due to the presence of more than one type of CE or CE-like activity. Expand
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