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Evidence for a role of sphingosine-1 phosphate in cardiovascular remodelling in Fabry disease.
AIMS A hallmark of Fabry disease is the concomitant development of left-ventricular hypertrophy and arterial intima-media thickening, the pathogenesis of which is thought to be related to the… Expand
Increased carotid intima-media thickness in the absence of atherosclerotic plaques in an adult population with Fabry disease.
- F. Barbey, N. Brakch, +5 authors D. Hayoz
- Acta paediatrica (Oslo, Norway : ). Supplement
- 1 April 2006
AIM Fabry disease is considered primarily as a progressive small vessel disease, with ischaemic degenerative lesions involving the kidneys, brain and heart. Macrovascular involvement in male patients… Expand
Dibasic cleavage site is required for sorting to the regulated secretory pathway for both pro‐ and neuropeptide Y
- N. Brakch, Flore Allemandou, C. Cavadas, E. Grouzmann, H. Brunner
- Biology, Medicine
- Journal of neurochemistry
- 1 June 2002
To investigate the signals governing routing of biologically active peptides to the regulated secretory pathway, we have expressed mutated and non‐mutated proneuropeptide Y (ProNPY) in… Expand
Rapid Site-Directed Mutagenesis Using Two-PCR-Generated DNA Fragments Reproducing the Plasmid Template
- Flore Allemandou, J. Nussberger, H. Brunner, N. Brakch
- Biology, Medicine
- Journal of biomedicine & biotechnology
- 20 August 2003
We describe a new rapid and efficient polymerase chain reaction (PCR)-based site-directed mutagenesis method. This procedure is effective with any plasmid and it employs four oligonucleotide primers.… Expand
The somatostatin-28(1-12)-NPAMAP sequence: an essential helical-promoting motif governing prosomatostatin processing at mono- and dibasic sites.
Proline residues, known to have special structural properties, induce particular conformations which participate in some biological functions. Two prolines (Pro(-9), Pro(-5)) located near the… Expand
Aortic remodelling in Fabry disease.
AIMS To evaluate thoracic aortic dilation in patients with Fabry disease (FD). METHODS AND RESULTS A cohort of 106 patients with FD (52 males; 54 females) from three European centres were studied.… Expand
Favourable side-chain orientation of cleavage site dibasic residues of prohormone in proteolytic processing by prohormone convertase 1/3.
- N. Brakch, M. Rholam, M. Simonetti, P. Cohen
- Medicine, Chemistry
- European journal of biochemistry
- 1 March 2000
Previous studies using selectively modified pro-ocytocin/neurophysin substrate analogues and the purified metalloprotease, pro-ocytocin/neurophysin convertase (magnolysin; EC 3.4 24.62), have shown… Expand
Measurement of plasma endothelin-1 in experimental hypertension and in healthy subjects.
- S. Abdel-Sayed, J. Nussberger, J. F. Aubert, P. Gohlke, H. Brunner, N. Brakch
- American journal of hypertension
- 1 July 2003
BACKGROUND Endothelin-1 is an endothelium-derived potent vasoconstrictor peptide of 21 amino acids. To establish reference values in different models of hypertension and in human subjects an assay… Expand
Abnormalities of peptide metabolism in Alzheimer disease.
The steady-state level of peptide hormones represents a balance between their biosynthesis and proteolytic processing by convertases and their catabolism by proteolytic enzymes. Low levels of… Expand
Clearance of amyloid-beta peptide by neuronal and non-neuronal cells: proteolytic degradation by secreted and membrane associated proteases.
- Maï Panchal, N. Lazar, +7 authors M. Rholam
- Medicine, Biology
- Current neurovascular research
- 31 October 2007
Deposition of amyloid-beta peptide (Abeta) in the brain is an early and invariant feature of all forms of Alzheimer's disease (AD). As for all proteins or peptides, the steady-state level of Abeta… Expand