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Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats
- N. Braidy, G. Guillemin, Hussein Mansour, T. Chan-Ling, A. Poljak, R. Grant
- BiologyPloS one
- 26 April 2011
The results are the first to show a significant decline in intracellular NAD+ levels and NAD∶NADH ratio in all organs by middle age compared to young rats, and suggest that adequate NAD+ concentrations may be an important longevity assurance factor.
Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue
- Hassina Massudi, R. Grant, N. Braidy, J. Guest, Bruce Farnsworth, G. Guillemin
- BiologyPloS one
- 27 July 2012
Nicotinamide adenine dinucleotide (NAD+) is an essential electron transporter in mitochondrial respiration and oxidative phosphorylation. In genomic DNA, NAD+ also represents the sole substrate for…
Targeting the TLR4 signaling pathway by polyphenols: A novel therapeutic strategy for neuroinflammation
Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson's Disease
- K. Tamilselvam, N. Braidy, G. Guillemin
- Biology, ChemistryOxidative medicine and cellular longevity
- 24 September 2013
The data suggests that hesperidin exerts its neuroprotective effect against rotenone due to its antioxidant, maintenance of mitochondrial function, and antiapoptotic properties in a neuroblastoma cell line.
Dysregulation of lipids in Alzheimer's disease and their role as potential biomarkers
Excitotoxic potential of the cyanotoxin β-methyl-amino-L-alanine (BMAA) in primary human neurons.
Is Alzheimer's a disease of the white matter?
White matter abnormalities not only represent an early neuropathological event in Alzheimer's disease but may also play an important role in the pathogenesis and diagnosis of Alzheimer's Disease.
Signaling pathway cross talk in Alzheimer’s disease
- J. Godoy, Juvenal A. Ríos, J. Zolezzi, N. Braidy, N. Inestrosa
- BiologyCell Communication and Signaling
- 28 March 2014
A new set of signaling pathways, collectively termed “anti-ageing pathways”, are highlighted for their potentiality in multi-target therapies against AD where cellular metabolic processes are severely impaired.
NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns
- Hassina Massudi, R. Grant, G. Guillemin, N. Braidy
- BiologyRedox report : communications in free radical…
- 1 January 2012
This review emphasizes the pivotal role of NAD+ in the regulation of DNA repair, stress resistance, and cell death, suggesting that NAD+ synthesis through the kynurenine pathway and/or salvage pathway is an attractive target for therapeutic intervention in age-associated degenerative disorders.