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Anatomic pairing of afferent arterioles and renin cell distribution in rat kidneys.
- D. Casellas, M. Dupont, N. Bouriquet, L. Moore, A. Artuso, A. Mimran
- Biology, MedicineThe American journal of physiology
- 1 December 1994
Rat arteriolar renin status, ranging from no renin cells to renin-recruited midafferent arterioles, distributed in a significantly nonrandom fashion within AA pairs, and 52% of the pairs had equal renin Status, suggesting AA pairing is a consistent anatomic characteristic of mammalian kidneys and may constitute an optimal vascular design for hemodynamic as well as endocrine interactions.
Prevention of the cardiovascular and renal effects of angiotensin II by endothelin blockade.
In conclusion, endogenous endothelin contributes to the cardiovascular and renal effects of Ang II, and the dipsogenic action of angiotensin II was not influenced by bosentan.
Insulin-like growth factor-I restores microvascular autoregulation in experimental chronic renal failure.
- J. J. Lin, B. Tönshoff, N. Bouriquet, D. Casellas, F. Kaskel, L. Moore
- Medicine, BiologyKidney international. Supplement
- 1 September 1998
It is suggested that IGF-I may protect the glomerulus from injury by maintaining autoregulatory control of renal blood flow, thereby slowing the progression of CRF.
Bosentan prevents preglomerular alterations during angiotensin II hypertension.
Chronic Ang II-induced hypertension is associated with the development of SB+ lesions and selective impairment of AR in juxtamedullary nephrons and endothelin-1 likely mediates the structurofunctional alterations of preglomerular vasculature during Ang II hypertension.
New Method for Imaging Innervation of the Renal Preglomerular Vasculature. Alterations in Hypertensive Rats
- D. Casellas, N. Bouriquet, A. Artuso, B. Walcott, L. Moore
- Medicine, BiologyMicrocirculation
- 1 December 2000
To assess nerve densities and vascular lesions along arcuate arteries, arcuate arterial branches, and interlobular arteries in spontaneously hypertensive rats and in angiotensin II and in NG‐nitro‐l‐arginine methyl ester hypertensive Rats.
Preglomerular sudanophilia in L-NAME hypertensive rats: involvement of endothelin.
L-NAME hypertension leads to rapid development of focal, inflammatory, proliferative, and sudanophilic lesions along preglomerular vessels, suggesting atherosclerosis-like processes, and endothelin is a likely mediator in the development of these lesions.
Chronic L-NAME hypertension in rats and autoregulation of juxtamedullary preglomerular vessels.
Chronic L-NAME hypertension is associated with a selective loss of vascular autoregulation in JMNs, which may contribute to glomerular injury.
Interaction between cGMP-dependent dilators and autoregulation in rat preglomerular vasculature.
The present results demonstrate that compounds known to utilize the cGMP-signaling pathway act as modulators of AR along the juxtamedullary preglomerular vasculature.
Branching patterns and autoregulatory responses of juxtamedullary afferent arterioles.
Around branching sites, AR are spatially organized in a way consistent with electrotonic vascular coupling in paired JMN, and in both AA branching patterns, EAA and nearby sites of the feed arteries had similar AR.
Nitric oxide and preglomerular vascular lesions in lyon spontaneously hypertensive rats.
Endogenous nitric oxide production provides protection against vascular barotrauma and Immunoreactive endothelin-1 likely plays an autocrine/paracrine role in vascular lesion formation.