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Use of factor IX complex in warfarin-related intracranial hemorrhage.
OBJECTIVE Anticoagulation-treated patients presenting with intracranial hemorrhage, including subdural hematoma, epidural hematoma, subarachnoid hemorrhage, and intracerebral hemorrhage, require… Expand
Lumbar Intraspinal Injection of Neural Stem Cells in Patients with Amyotrophic Lateral Sclerosis: Results of a Phase I Trial in 12 Patients
Advances in stem cell biology have generated intense interest in the prospect of transplanting stem cells into the nervous system for the treatment of neurodegenerative diseases. Here, we report the… Expand
Gene therapy for neurodegenerative diseases.
Gene therapy is, potentially, a powerful tool for treating neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy, Parkinson's disease (PD) and Alzheimer's… Expand
Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double‐blind, randomized, controlled trial
A 12‐month double‐blind sham‐surgery–controlled trial assessing adeno‐associated virus type 2 (AAV2)‐neurturin injected into the putamen bilaterally failed to meet its primary endpoint, but showed… Expand
The S cell: an interneuron essential for sensitization and full dishabituation of leech shortening
- C. Sahley, B. Modney, N. Boulis, K. Muller
- Biology, Medicine
- The Journal of neuroscience : the official…
- 1 November 1994
Sensory neurons in the leech excite the S interneuron, which in turn excites motoneurons that shorten the leech, although activity in the S cell reportedly cannot by itself shorten the animal.… Expand
Progress in gene therapy for neurological disorders
CORRECTION Progress in gene therapy for neurological disorders Michele Simonato, Jean Bennett, Nicholas M. Boulis, Maria G. Castro, David J. Fink, William F. Goins, Steven J. Gray, Pedro R.… Expand
Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients
Objective: In an effort to account for deficiencies in axonal transport that limit the effectiveness of neurotrophic factors, this study tested the safety and feasibility, in moderately advanced… Expand
Stem cell technology for the study and treatment of motor neuron diseases.
- J. Lunn, S. A. Sakowski, T. Federici, J. Glass, N. Boulis, E. Feldman
- Regenerative medicine
- 11 March 2011
Amyotrophic lateral sclerosis and spinal muscular atrophy are devastating neurodegenerative diseases that lead to the specific loss of motor neurons. Recently, stem cell technologies have been… Expand
Intracerebral Hemorrhage-induced Neuronal Death
OBJECTIVEThe mechanisms underlying neural injury in intracerebral hemorrhage (ICH) remain uncertain. The present two-part study investigated cell death in the region of ICH and its association with… Expand
Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs
Adeno-associated viral vector 9 (AAV9) has recently been shown to penetrate the blood–brain barrier via intravascular administration, making it a good candidate for diffuse gene delivery. However,… Expand