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Identification and validation of an ERBB2 gene expression signature in breast cancers
ERBB2 is a transmembrane tyrosine kinase receptor encoded by a gene located in chromosome region 17q12. Overexpression of ERBB2, generally by way of gene amplification, plays a role in mammary… Expand
Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II
Abstract The lymphocyte activation gene-3 (LAG-3), a major histocompatibility complex (MHC) class II ligand evolutionarily related to CD4, is expressed exclusively in activated T and NK lymphocytes… Expand
Tissue-specificity of 412 retrotransposon expression in Drosophila simulans and D. melanogaster
- N. Borie, C. Maisonhaute, S. Sarrazin, C. Loevenbruck, C. Biémont
- Medicine, Biology
- 1 October 2002
We analyse the expression of the retrotransposon 412 in the soma, testes, and ovaries in populations of Drosophila simulans and D. melanogaster, using RT-PCR and in situ hybridization. We find that… Expand
Genomic organization of the human LAG-3/CD4 locus
Efficient T-cell activation leading to clonal expansion and differentiation requires a signal derived from the T-cell receptor (TCR)/CD3 complex and a second signal mediated by CD28. In the absence… Expand
Transposable elements and genome evolution: the case of Drosophila simulans
Drosophila simulans presents a large variation in copy number among various transposable elements (TEs) and among natural populations for a given element. Some elements such as HMS beagle, blood,… Expand
Developmental expression of the 412 retrotransposon in natural populations of D. melanogaster and D. simulans.
We analysed the pattern of expression of retrotransposon 412 through developmental stages in various populations of Drosophila simulans and D. melanogaster differing in 412 copy number. We found that… Expand
Breast Cancer ProfileChip: from large scale gene expression profiling to oncodiagnostic device
Éléments transposables et évolution du génome d’une espèce invasive: le cas de Drosophila simulans
Les deux espèces jumelles D. melanogaster et D. simulans diffèrent pour leur nombre global de copies d’éléments transposables (ETs) de leur génome. D. simulans a moins de copies que D. melanogaster… Expand
Identification of a specific model of the expression of ErbB2 gene in breast cancer.