Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat.
- J. Simpkins, G. Rajakumar, A. Day
- Biology, MedicineJournal of Neurosurgery
- 1 November 1997
The present study provides the first evidence that estrogens exert neuroprotective effects in an animal model of ischemia and suggests that estrogen may be a useful therapy to protect neurons against the neurodegenerative effects of stroke.
Ophthalmic drug design based on the metabolic activity of the eye: Soft drugs and chemical delivery systems
- N. Bodor, P. Buchwald
- Medicine, BiologyAAPS Journal
- 7 December 2005
This review will concentrate on-adrenergic agonists and anti-inflammatory corticosteroids, where clinical results obtained with new chemical entities exist to support the advantages of such metabolism-focused, ophthalmic-specific drug design approaches.
Octanol-water partition: searching for predictive models.
- P. Buchwald, N. Bodor
- ChemistryCurrent Medicinal Chemistry
- 1 October 1998
The recently developed, molecular size-based approach is reviewed, and it is argued that introduction of three-dimensionality allows the elimination of many empirically derived fragment constants without a significant deterioration of the predictive accuracy.
Soft drugs—10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: Loteprednol etabonate
- P. Druzgala, G. Hochhaus, N. Bodor
- Chemistry, BiologyJournal of Steroid Biochemistry and Molecular…
- 1 February 1991
Receptor binding studies of soft anticholinergic agents
- F. Huang, P. Buchwald, N. Bodor
- Biology, ChemistryAAPS PharmSci
- 1 December 2001
The potency as measured by the pK i values was found to be related to geometric, electronic, and lipophilicity descriptors for the soft anticholinergics containing at least 1 tropine moiety in their structure.
Brain-Targeted Drug Delivery
- N. Bodor, P. Buchwald
- Biology
- 1 March 2003
Site-target indexing and the use of targeting enhancement factors can be used to quantitatively assess the site-targeting effectiveness from a pharmacokinetic perspective of chemical delivery systems.
Soft glucocorticoid design: structural elements and physicochemical parameters determining receptor-binding affinity.
- P. Buchwald, N. Bodor
- Biology, ChemistryPharmazie
- 1 May 2004
According to data, receptor binding affinity at the GR is dramatically increased by 6alpha- or 9alpha-halogenation and it also tends to increase with increasing lipophilicity, which accounts for a large portion of the variability in RBA.
Use of 2-Hydroxypropyl-β-cyclodextrin as a Solubilizing and Stabilizing Excipient for Protein Drugs
- M. Brewster, M. Hora, J. Simpkins, N. Bodor
- ChemistryPharmaceutical Research
- 1 June 1991
Data suggest that this starch derivative may be a potentially useful excipient for protein drugs intended for parenteral use and the safety of HPCD and its well-characterized chemical composition are suggested.
Improved delivery through biological membranes. XXII. Synthesis and distribution of brain-selective estrogen delivery systems
- N. Bodor, J. McCornack, M. Brewster
- Biology, Chemistry
- 1 February 1987
Improved delivery through biological membranes. 3. Delivery of N-methylpyridinium-2-carbaldoxime chloride through the blood-brain barrier in its dihydropyridine pro-drug form.
- E. Shek, T. Higuchi, N. Bodor
- Chemistry, BiologyJournal of Medicinal Chemistry
- 1976
Administration of N-methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride, the pro-drug form of 2-PAM, resulted in an average of 13-fold increase in the amount of 2-PAM delivered into the brain of…
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