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Folate deficiency alone does not produce neural tube defects in mice.
The incidence of neural tube defects was studied in mouse embryos from dams fed an amino acid-based diet containing 45, 91, 136, 181, 227 or 453 nmol folic acid/kg diet (Experiment 1) or 227, 453,Expand
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Ineffective hematopoiesis in folate-deficient mice.
A folate-free amino acid-based diet provided an opportunity to characterize the effects of folate depletion on growth, tissue folate levels, and hematopoiesis of mice under well-standardizedExpand
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Repletion of folate-depleted rats with an amino acid-based diet supplemented with folic acid.
Folate depletion and repletion protocols are not well standardized. Weanling rats were moderately depleted of folate in 28 d with a folate-free purified diet based on 17% amino acids as the nitrogenExpand
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Bioavailability of food folates and evaluation of food matrix effects with a rat bioassay.
Folate bioavailability of beef liver, lima beans, peas, spinach, mushrooms, collards, orange juice and wheat germ was estimated with a protocol of folate depletion-repletion using growth and liver,Expand
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Delayed tumor onset in transgenic mice fed an amino acid-based diet supplemented with red wine solids.
Increased consumption of vegetable foods (cereals, legumes, fruits) and some beverages (tea, cider, wine) is associated with reduced risk of cancer. Polyphenols in these foods and beverages areExpand
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Delayed tumor onset in transgenic mice fed a low-folate diet.
BACKGROUND Transgenic mice carrying the human T-lymphotropic virus type 1 tax1 (transactivator) gene develop peripheral nerve sheath tumors with well-characterized times of onset and tissueExpand
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Tissue distribution and prediction of total body folate of rats.
To clarify relationships between dietary folic acid intake, blood levels and body stores of folate, rats were fed an amino acid-based diet supplemented with 0, 0.125, 0.5, 1, 2 or 4 mg folic acid/kgExpand
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Phorbol esters modulate the phosphorylation of human T-cell leukemia virus type I Tax.
The Tax protein from human T-cell leukemia virus type I (HTLV-I) is a 40-kDa phosphoprotein capable of activating transcription from its own long terminal repeat (LTR), as well as increasing theExpand
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Bioavailability of folates in selected foods incorporated into amino acid-based diets fed to rats.
Two experiments were conducted to determine the feasibility of using a folate depletion/repletion protocol with rats fed an amino acid-based diet to measure the bioavailability of food folate.Expand
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A depletion-repletion folate bioassay based on growth and tissue folate concentrations of rats.
To improve standardization of a folate bioassay, folate-depleted rats were repleted with a folate-free amino acid-based diet supplemented with 29 levels of folic acid. Growth was the main responseExpand
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