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Diclofenac release from eudragit-containing matrices and effects of thermal treatment.
TLDR
Ethyl acrylate-methyl methacrylate copolymer (Eudragit NE40D) was evaluated as matrix material for preparing controlled-release tablets of diclofenac sodium and found to have matrix of higher tortuosity and lower porosity. Expand
Curcumin-containing chitosan nanoparticles as a potential mucoadhesive delivery system to the colon
TLDR
Curcumin release from CS-NPs was slowest at chitosan to TPP weight ratio of 3:1, with a significant retention at the end of 6 h, suggesting a monolayer-limited adsorption on heterogeneous sites with varied affinities. Expand
Cellular uptake and anticancer effects of mucoadhesive curcumin-containing chitosan nanoparticles.
TLDR
The prolonged contact offered by the mucoadhesion of CUR-CS-NP onto the cells resulted in a greater reduction in percentage cell viability as well as a lower IC50, indicating a potential improved treatment outcome. Expand
Surfactant effects on the physical characteristics of Amphotericin B-containing nanostructured lipid carriers
In the present study, we investigate the effects of various surfactants/lipid combinations and processing variables on the physical properties of Amphotericin B-loaded nanostructured lipid carriersExpand
A Gastrointestinal Transit Study on Amphotericin B-Loaded Solid Lipid Nanoparticles in Rats
TLDR
The gastrointestinal (GI) transit behavior of and absorption from an amphotericin B (AmB) solid lipid nanoformulation (SLN) in rats was investigated and AmB within SLN was favorably absorbed from the small intestine, albeit slowly. Expand
A dual-application poly (dl-lactic-co-glycolic) acid (PLGA)-chitosan composite scaffold for potential use in bone tissue engineering
TLDR
A novel dual-application scaffold system was formulated from porous PLGA and protein-loaded PLGA/chitosan microspheres, showing cytocompatibility with primary human mesenchymal stem cells and osteogenic properties and demonstrating its injectable potential. Expand
Gamma-scintigraphic study of the gastrointestinal transit and in vivo dissolution of a controlled release diclofenac sodium formulation in xanthan gum matrices.
TLDR
The gastrointestinal transit behaviour of the formulation as determined by gamma scintigraphy, using healthy male volunteers under fasted and fed conditions, indicated that gastric emptying was delayed with food intake, and the small intestinal transit remained practically unchanged under both food statuses. Expand
An Evaluation of Curcumin-Encapsulated Chitosan Nanoparticles for Transdermal Delivery
TLDR
Cu-NPs developed in this study exhibit superior drug release and enhanced transdermal permeation of curcumin and superior percentage cell viability and the interaction between the drug and the polymer is confirmed. Expand
Lipid Effects on Expulsion Rate of Amphotericin B from Solid Lipid Nanoparticles
TLDR
N nanoparticles made from equal concentrations of theobroma oil and beeswax produced the most desirable properties and worthy of further investigations. Expand
Bioavailability and pharmacokinetics of acyclovir tablet preparation.
TLDR
The bioavailability of a generic preparation of acyclovir (Avorax) was compared with the innovator product, Zovirax, and the elimination rate constant (k(e), elimination half-life (t(1/2), and apparent volume of distribution (Vd) values obtained were comparable and not significantly different statistically. Expand
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