Ebola virus disease in the Democratic Republic of Congo.
The current EVD outbreak in the DRC has clinical and epidemiologic characteristics that are similar to those of previous EVD outbreaks in equatorial Africa, and the causal agent is a local EBOV variant different from that in the 2014 epidemic in West Africa.
Molecular characterization of three Zika flaviviruses obtained from sylvatic mosquitoes in the Central African Republic.
Phylogenetic analysis based on the amino acid sequence of the polyprotein showed that the three ZIKV strains clustered together but diverged from all other ZikV strains, suggesting that a different subtype of West African ZIKv strains circulated in Aedes species in Central Africa.
First case of Elizabethkingia anophelis meningitis in the Central African Republic
Evaluation of High-Throughput Sequencing for Identifying Known and Unknown Viruses in Biological Samples
For the viruses represented, or resembling those represented, in public nucleotide sequence databases, it is shown that the higher output of Illumina is associated with a much greater sensitivity, approaching that of optimized quantitative (RT-)PCRs.
Nomenclature- and Database-Compatible Names for the Two Ebola Virus Variants that Emerged in Guinea and the Democratic Republic of the Congo in 2014
In 2014, Ebola virus (EBOV) was identified as the etiological agent of a large and still expanding outbreak of Ebola virus disease (EVD) in West Africa and a much more confined EVD outbreak in Middle…
Phi29 polymerase based random amplification of viral RNA as an alternative to random RT-PCR
This is the first report in the scientific literature showing that a modified WGA (WTA) approach can be successfully applied to viral genomic RNA of all sizes.
A Nosocomial Outbreak of Human Monkeypox in the Central African Republic
An outbreak of familial monkeypox occurred in the Central African Republic in 2015/2016 by 3 transmission modes: familial, health care–related, and transport-related; the viral strain responsible was a Zaire genotype strain.
African Non-Human Primates Host Diverse Enteroviruses
The identification of two novel enterovirus types, EV-B112 in a chimpanzee andEV-B113 in a mandrill, suggests these NHPs could be potential sources of new EV types and the identification of chimpanzee-derived EV110 in a Mandrill demonstrated a wide host range of this EV.
Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018
The phylogenetic results indicate that the 10 CAR isolates belong to three lineages closely related to those found in DRC, and the phylogenetic pattern shows that all of them emerged in the rainforest block of the Congo Basin.
Application of Broad-Spectrum Resequencing Microarray for Genotyping Rhabdoviruses
This work analyzes the capacity for viral detection and identification of a newly described high-density resequencing microarray, termed PathogenID, which was designed for multiple pathogen detection using database similarity searching and demonstrates that this approach has the potential to identify both known and related viruses for which precise sequence information is unavailable.