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Solution Structure and Internal Motion of a Bioactive Peptide Derived from Nerve Growth Factor*
The conformation and internal dynamics of a bioactive cyclic peptide, N-acetyl-YCTDEKQCY, derived from the C-D loop of β-nerve growth factor (β-NGF) were analyzed by solution NMR spectroscopy. NMRExpand
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Genuine Monovalent Ligands of TrkA Nerve Growth Factor Receptors Reveal a Novel Pharmacological Mechanism of Action*
Developing small molecule agonistic ligands for tyrosine kinase receptors has been difficult, and it is generally thought that such ligands require bivalency. Moreover, multisubunit receptors areExpand
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Design and solution structure of functional peptide mimetics of nerve growth factor.
The C-D loop in nerve growth factor (NGF) is involved in binding to the NGF receptor, TrkA. It is flexible and adopts several different types conformations in different NGF crystal forms. We haveExpand
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1H, 15N and 13C NMR Assignments, Secondary Structure and Overall Topology of the Escherichia Coll Glgs Protein
GlgS is a 7892-Da protein which is involved in glycogen biosynthesis in bacteria. We report the 1H, 15N and 13C NMR assignments of the backbone and side-chain resonances at 25°C and pH 6.7 fromExpand
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1H, 15N and 13C NMR assignments, secondary structure and overall topology of the Escherichia coli GlgS protein.
GlgS is a 7892-Da protein which is involved in glycogen biosynthesis in bacteria. We report the 1H, 15N and 13C NMR assignments of the backbone and side-chain resonances at 25 degrees C and pH 6.7Expand
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Pharmacokinetics, Serum Stability and Immunogenicity of A Polypeptide Inhibitor of B2GPI/Antibody Complexes Tested in Mice.
Abstract 2205 Background: Antiphospholipid syndrome (APS) is an autoimmune disease with clinical features of thrombosis and pregnancy loss. Beta2-glycoprotein I (B2GPI) is the major antigen forExpand
A Novel Dimeric Inhibitor That Targets Dimeric ß2GPI In ß2GPI/Anti-ß2GPI Antibody Complexes.
Abstract 1142 s2GPI is a major antigen for autoantibodies associated with antiphospholipid syndrome, an autoimmune disease characterized by thrombosis and recurrent pregnancy loss. Only the dimericExpand
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