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Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory.
TLDR
This meningococcal conjugate vaccine was well tolerated and immunogenic and induced immunologic memory in infants and produced fewer local reactions than concurrent routine immunizations.
Communicable Disease Control Handbook
Section 1 - introduction section 2 - common topics section 3 - diseases section 4 - services and organization section 5 - communicable disease control in individual countries appendices - resources
A novel combined Hib-MenC-TT glycoconjugate vaccine as a booster dose for toddlers: a phase 3 open randomised controlled trial
TLDR
The waning antibody titres against Hib and MenC following primary immunisation can be boosted to protective levels by administering the Hib-MenC-TT vaccine at 12–15 months of age, supporting the recent introduction of this vaccine in the UK immunisation schedule.
Paralytic poliomyelitis in England and Wales, 1985-91.
TLDR
Indigenous wild poliovirus seems to have been eradicated, although wild virus may be imported; improved surveillance of suspected cases including immediate notification and characterisation of the virus to ensure that eradication is maintained is essential.
A report on the status of vaccination in Europe.
Virus excretion and mutation by infants following primary vaccination with live oral poliovaccine from two sources
TLDR
The excretion of virus by 30 children was followed over a period of 28 days after their first vaccination with live oral poliovaccine, and mutations in the 5′ non‐coding region associated with the attenuated phenotype reverted most rapid for type 3 and least rapidly for type 1.
Immunisation: causes of failure and strategies and tactics for success.
TLDR
The experience is that participants find that this approach leads to their developing a learner centred rather than a teacher centred approach to their training, and the self assessment process provides a sound foundation for more conventional audits.
A New Combination Haemophilus influenzae Type B and Neisseria meningitidis Serogroup C-Tetanus Toxoid Conjugate Vaccine for Primary Immunization of Infants
We conducted a phase 3 randomized controlled trial looking at the immunogenicity and safety of a novel combined Haemophilus influenzae type b and Neisseria meningitidis serogroup C tetanus toxoid
Epidemiology of invasive Haemophilus influenzae infections in England and Wales in the pre-vaccination era (1990–2)
TLDR
Diagnostic category varied with both age and serotype; meningitis was the commonest presentation overall but pneumonia and bacteraemia were more common in adults and non-typeable isolates and Mortality was highest in neonates and the elderly who were more likely to have an underlying predisposing condition.
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