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Errors in DNA replication as a basis of malignant changes.
Summary In this essay we have considered possible relationships between errors in DNA replication and malignant progression. Theoretical and experimental studies designed to determine the energy ofExpand
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Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.
Primary steps in the metabolism of caffeine and theophylline are cleavage of methyl groups and/or hydroxylation at position 8, mediated by cytochromes P450. V79 Chinese hamster cells geneticallyExpand
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Enteroviruses and type 1 diabetes mellitus.
Despite decades of research, the etiology of type 1 diabetes mellitus (DM) is unknown. Several risk factors have been associated with type 1 DM, including viral infections, genetic predisposition,Expand
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Selective mutagenic activation by cytochrome P3-450 of carcinogenic arylamines found in foods.
Heterocyclic arylamines found in cooked foods including fish and beef are potent mutagens and carcinogens. The purpose of this investigation was to determine the specificity of cytochromes P1-450 andExpand
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The infidelity of avian myeloblastosis virus deoxyribonucleic acid polymerase in polynucleotide replication.
Abstract We have studied the accuracy of DNA synthesis in vitro by purified avian myeloblastosis virus (AMV) DNA polymerase ("reverse transcriptase") using synthetic polynucleotide templates. TheExpand
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Metabolic activation of 2-acetylaminofluorene is required for induction of multidrug resistance gene expression in rat liver cells.
P-Glycoprotein the multidrug resistance (mdr) efflux transporter is encoded by class 1 mdr genes (mdr1) in humans and rodent species. In rat liver and in rat hepatocytes in primary culture,Expand
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Stable expression of human cytochrome P450IIE1 in mammalian cells: metabolic activation of nitrosodimethylamine and formation of adducts with cellular DNA.
To introduce cytochrome P450IIE1 DNA stably into the chromosomal DNA of mammalian cells, we constructed recombinant retroviruses containing the full-length complementary DNA for human cytochromeExpand
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Retrovirus-mediated stable expression of human CYP2A6 in mammalian cells.
To study the pharmacological and toxicological significance of the human cytochrome P450 isoform CYP2A6, we expressed it in mammalian cells by retrovirus-mediated gene transfer. The LXSN vector andExpand
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