• Publications
  • Influence
The complete atomic structure of the large ribosomal subunit at 2.4 A resolution.
The crystal structure of the large ribosomal subunit from Haloarcula marismortui is determined at 2.4 angstrom resolution, and it includes 2833 of the subunit's 3045 nucleotides and 27 of its 31 proteins. Expand
The structural basis of ribosome activity in peptide bond synthesis.
It is established that the ribosome is a ribozyme and the catalytic properties of its all-RNA active site are addressed and the mechanism of peptide bond synthesis appears to resemble the reverse of the acylation step in serine proteases. Expand
Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1
The structure provides insight into how protein synthesis is initiated and into the evolution of the eukaryotic ribosome, including the function of eIF1 as well as signaling and regulation mediated by the ribosomal proteins RACK1 and rpS6e. Expand
The structures of four macrolide antibiotics bound to the large ribosomal subunit.
Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16-membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15-membered macrolide,Expand
Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6
The 3.5 angstrom–resolution structure of the 60S ribosomal subunit from Tetrahymena thermophila in complex with eukaryotic initiation factor 6 (eIF6), cocrystallized with the antibiotic cycloheximide, elucidates the molecular basis of the interaction with eIF6 and provides a structural framework for further studies of ribosome-associated diseases. Expand
RNA tertiary interactions in the large ribosomal subunit: The A-minor motif
The A-minor motif is by far the most abundant tertiary structure interaction in the large ribosomal subunit; 186 adenines in 23S and 5S rRNA participate, 68 of which are conserved. Expand
L23 protein functions as a chaperone docking site on the ribosome
It is concluded that essential L23 provides a chaperone docking site on ribosomes that directly links protein biosynthesis with chaper one-assisted protein folding. Expand
The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins
The early co-translational events involving the ribosome that guide cytosolic proteins to their native state are reviewed. Expand
The complete structure of the 55S mammalian mitochondrial ribosome
The structure reveals the intersubunit contacts in the 55S mitoribosome, the molecular architecture of the mitorIBosomal messenger RNA binding channel and its interaction with transfer RNAs, and provides insight into the highly specialized mechanism of mRNA recruitment to the 28S subunit. Expand
Structural basis of enzyme encapsulation into a bacterial nanocompartment
It is shown, using X-ray crystallographic, biochemical and EM experiments, that a widespread family of conserved bacterial proteins, the linocin-like proteins, form large assemblies that function as a minimal compartment to package enzymes. Expand