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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution.
The crystal structure of the large ribosomal subunit from Haloarcula marismortui is determined at 2.4 angstrom resolution, and it includes 2833 of the subunit's 3045 nucleotides and 27 of its 31 proteins.
The structural basis of ribosome activity in peptide bond synthesis.
It is established that the ribosome is a ribozyme and the catalytic properties of its all-RNA active site are addressed and the mechanism of peptide bond synthesis appears to resemble the reverse of the acylation step in serine proteases.
Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1
The structure provides insight into how protein synthesis is initiated and into the evolution of the eukaryotic ribosome, including the function of eIF1 as well as signaling and regulation mediated by the ribosomal proteins RACK1 and rpS6e.
The structures of four macrolide antibiotics bound to the large ribosomal subunit.
RNA tertiary interactions in the large ribosomal subunit: The A-minor motif
- P. Nissen, J. Ippolito, N. Ban, P. Moore, T. Steitz
- BiologyProceedings of the National Academy of Sciences…
- 10 April 2001
The A-minor motif is by far the most abundant tertiary structure interaction in the large ribosomal subunit; 186 adenines in 23S and 5S rRNA participate, 68 of which are conserved.
Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins
New light is shed on the understanding of co-translational protein folding, and an unexpected mechanism of action for ribosome-associated chaperones is suggested.
Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6
- S. Klinge, F. Voigts-Hoffmann, M. Leibundgut, S. Arpagaus, N. Ban
- Biology, ChemistryScience
- 18 November 2011
The 3.5 angstrom–resolution structure of the 60S ribosomal subunit from Tetrahymena thermophila in complex with eukaryotic initiation factor 6 (eIF6), cocrystallized with the antibiotic cycloheximide, elucidates the molecular basis of the interaction with eIF6 and provides a structural framework for further studies of ribosome-associated diseases.
The Crystal Structure of a Mammalian Fatty Acid Synthase
The structural comparison of mammalian fatty acid synthase with modular polyketide synthases shows how their segmental construction allows the variation of domain composition to achieve diverse product synthesis.
Structure of the Eukaryotic Thiamine Pyrophosphate Riboswitch with Its Regulatory Ligand
The 2.9 angstrom–resolution crystal structure of the eukaryotic Arabidopsis thaliana thiamine pyrophosphate–specific riboswitch in complex with its natural ligand explains the mechanism of resistance to the antibiotic pyrithiamine.
L23 protein functions as a chaperone docking site on the ribosome
It is concluded that essential L23 provides a chaperone docking site on ribosomes that directly links protein biosynthesis with chaper one-assisted protein folding.