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Glutathione dysregulation and the etiology and progression of human diseases
- N. Ballatori, Suzanne M Krance, S. Notenboom, Shujie Shi, K. Tieu, C. Hammond
- BiologyBiological chemistry
- 1 March 2009
The present report highlights and integrates the growing connections between imbalances in GSH homeostasis and a multitude of human diseases and suggests the high GSH content makes cancer cells chemoresistant, which is a major factor that limits drug treatment.
Mechanisms of mercury disposition in the body.
Today the most widespread human exposures to mercury are to mercury vapor emitted from amalgam tooth fillings, to ethylmercury as a preservative in vaccines, and to methylmercury in edible tissues of…
The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter.
Results demonstrate that the mouse Ostalpha-Ostbeta heteromeric transporter is a basolateral bile acids carrier and may be responsible for bile acid efflux in ileum and other ASBT-expressing tissues.
OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.
The selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption, the substrate selectivity of the transporter, and the facilitated diffusion transport mode collectively indicate that OST alpha-OSTbeta is a key basol lateral transporter for the re absorption of these important steroid-derived molecules.
Endogenous glutathione conjugates: occurrence and biological functions.
Glutathione (GSH)b performs a variety of important physiological and metabolic functions in all mammalian cells, including the detoxification of free radicals, metals, and other electrophilic…
OSTα‐OSTβ: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
selective localization of OSTα and OSTβ to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption, the substrate selectivity of the transporter, and the facilitated diffusion transport mode collectively indicate that OST α‐OSTβ is a key Basolateral transporter for the re absorption of these important steroid‐derived molecules.
The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway
It is shown that the organic cation transporter 3 (Oct3) is expressed in nondopaminergic cells adjacent to both the soma and terminals of midbrain dopaminergic neurons, which may have far-reaching implications for the understanding of the mechanism of cell death in a wide range of neurodegenerative diseases and may open new avenues for neuroprotective intervention.
Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology.
Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins.
Identification of Glutathione as a Driving Force and Leukotriene C4 as a Substrate for oatp1, the Hepatic Sinusoidal Organic Solute Transporter*
Oatp1-mediated taurocholate and LTC4 uptake was cis-inhibited and trans-stimulated by GSH, and [3H]GSH efflux was enhanced in the presence of extracellular tau rocholate or sulfobromophthalein, indicating that G SH efflux down its large electrochemical gradient provides the driving force for uptake via oatp 1.