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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
TLDR
It is suggested that proinsulin is a primary autoantigen of the NOD mouse, and speculate that organ-restricted autoimmune disorders with marked major histocompatibility complex (MHC) restriction of disease are likely to have specificPrimary autoantigens.
Prevention and Treatment of Obesity, Insulin Resistance, and Diabetes by Bile Acid–Binding Resin
TLDR
The molecular basis for a link between bile acids and glucose metabolism is provided and the bile acid metabolism pathway is suggested as a novel therapeutic target for the treatment of obesity, insulin resistance, and type 2 diabetes.
Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level.
TLDR
It is demonstrated that the HNF-1 alpha gene locus is associated with serum HDL-c level and suggested that the Ile27 allele is a risk marker for atherosclerosis.
Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse
TLDR
Nucleotide sequencing suggests that Glut4 is unlikely to be a candidate gene for Nidd1nsy (a susceptibility gene for Type II diabetes) on Chromosome 11, encoding insulin-sensitive glucose transporter, in NSY and C3H mice.
Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West.
TLDR
The discovered similarities and differences in susceptibility genes for type 1 diabetes between East and West are reported and genetic heterogeneity may exist regarding SUMO4, with an association of the M55V variant withType 1 diabetes observed in Asians, but not in Caucasians.
The Stages of Type 1A Diabetes
TLDR
It is shown that type 1 diabetes in man can be predicted because it is a chronic autoimmune disorder with defined stages of disease, and it can also readily prevent the disorder in animal models.
Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet.
TLDR
Data suggest that elucidation of this heterogeneity in response to HSD might contribute to further understanding of the gene-environment interactions leading to diabetes in humans.
Food hardness as environmental factor in development of type 2 diabetes.
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