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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
ENDOGENOUS neuromodulatory molecules are commonly coupled to specific metabolic enzymes to ensure rapid signal inactivation. Thus, acetylcholine is hydrolysed by acetylcholine esterase1 andExpand
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The Gap Junction Communication Channel
We thank Nancy Kauler for her superb secretarial assistance. In addition, we are extremely grateful to Dr. Matthias Falk for his helpful comments concerning the content of this manuscript. Owing toExpand
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Three-dimensional structure of a recombinant gap junction membrane channel.
Gap junction membrane channels mediate electrical and metabolic coupling between adjacent cells. The structure of a recombinant cardiac gap junction channel was determined by electron crystallographyExpand
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Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice.
Gap junction channels formed by alpha3 (Cx46) and alpha8 (Cx50) connexin provide pathways for communication between the fiber cells in the normal transparent lens. To determine the specific role ofExpand
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Topology of the 32‐kd liver gap junction protein determined by site‐directed antibody localizations.
Synthetic peptides corresponding to sequences in the human liver gap junction protein were chemically synthesized and used for generation of peptide antisera to defined sequences in the protein. TheExpand
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The Sleep-inducing Lipid Oleamide Deconvolutes Gap Junction Communication and Calcium Wave Transmission in Glial Cells
Oleamide is a sleep-inducing lipid originally isolated from the cerebrospinal fluid of sleep-deprived cats. Oleamide was found to potently and selectively inactivate gap junction–mediatedExpand
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Intramembrane organization of specialized contacts in the outer plexiform layer of the retina. A freeze-fracture study in monkeys and rabbits
Freeze-fracture analysis of the neural connections in the outer plexiform layer of the retina of primates (Macaca mulatta and Macaca arctoides) demonstrates a remarkable diversity in the internalExpand
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Disruption of α3Connexin Gene Leads to Proteolysis and Cataractogenesis in Mice
Abstract Gap junction channels formed by α 3 (Cx46) and α 8 (Cx50) connexin provide pathways for communication between the fiber cells in the normal transparent lens. To determine the specific roleExpand
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Chemical characterization of a family of brain lipids that induce sleep.
A molecule isolated from the cerebrospinal fluid of sleep-deprived cats has been chemically characterized and identified as cis-9,10-octadecenoamide. Other fatty acid primary amides in addition toExpand
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On signal sequence polymorphisms and diseases of distribution.
We report a previously unappreciated property of the signals that target organelle-specific proteins to their subcellular sites of action. Such targeting sequences are shown to be polymorphic. WeExpand
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