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Towards More Realistic In Vitro Release Measurement Techniques for Biodegradable Microparticles
Great care must be taken when defining the in vitro conditions for drug release measurements from biodegradable microparticles, due to the small size of the drug molecules/ions with respect to the hydrogel mesh size. Expand
Determination of glyphosate in biological fluids by 1H and 31P NMR spectroscopy.
Characterization of the N-(phosphonomethyl) glycine herbicide was achieved by chemical shift considerations and coupling constant patterns, confirming the ingestion of the considered trade formulation. Expand
Use of 15N reverse gradient two-dimensional nuclear magnetic resonance spectroscopy to follow metabolic activity in Nicotiana plumbaginifolia cell-suspension cultures
The occurrence of 15N-label in agmatine and the low detection of labelled putrescine indicate that crucial intermediates of the pathway from glutamate to polyamines and/or the tobacco alkaloids could be monitored. Expand
1H-NMR analysis of trimethylamine in urine for the diagnosis of fish-odour syndrome.
The use of proton NMR spectroscopy for the analysis of trimmedethylamine in the urine of a patient with trimethylaminuria and analysis was also performed for other members of his family. Expand
Comparative study of the complex forming ability and enantioselectivity of cyclodextrin polymers by CE and 1H NMR.
The 2D-NMR results seem to indicate that the structure of the polymeric network favours the inclusion of the guest in the hydrophobic cavity of the CD units, and the poly-CDs have shown very high enantioselective abilities at both pH.5 and 7.0. Expand
Identification and quantitation of xenobiotics by 1H NMR spectroscopy in poisoning cases.
NMR investigations were applied to acute poisoning cases, involving drugs such as salicylates and valproic acid, and an intentional poisoning case with tetrahydrofuran, which allowed the determination of many exogenous and endogenous compounds, without any pre-selection of the analytes. Expand
Unusual inversion phenomenon of β-cyclodextrin dimers in water.
A conformational analysis of three triazole-containing bridged bis-β- cyclodextrins (CD) has been carried out to evaluate their recognition ability. NMR spectroscopy and ITC measurements clearlyExpand
Configurational stability of 9-hydroxyrisperidone. Kinetics and mechanism of racemization
Abstract The configurational stability of 9-hydroxyrisperidone, an atypical antipsychotic, was studied under acidic, basic and physiological conditions. The analysis of 9-hydroxyrisperidone wasExpand
Design, synthesis and glutathione peroxidase-like properties of ovothiol-derived diselenides.
Eleven imidazole diselenides derived from the naturally occurring family of antioxidants, the ovothiols, were synthetised by cyclisation of selenoamides with trimethylsilyltrifluoromethanesulfonateExpand
Plant therapy in the Peruvian Amazon (Loreto) in case of infectious diseases and its antimicrobial evaluation.
An a posteriori correlation of the plant extract antimicrobial activity with the chemosensory cues of the drugs is suggested and it is attested that those chemosENSory cues may be correlated with the presence of antimicrobial compounds. Expand