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The role of phase synchronization in memory processes
This work proposes that processes underlying working and long-term memory might interact in the medial temporal lobe and proposes that this is accomplished by neural operations involving phase–phase and phase–amplitude synchronization. Expand
Cross-frequency coupling supports multi-item working memory in the human hippocampus
Intracranial EEG recordings in human epilepsy patients are used to test pivotal predictions from theoretical work and show that simultaneous maintenance of multiple items in WM is accompanied by cross-frequency coupling of oscillatory activity in the hippocampus, which is recruited during multi-item WM. Expand
Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep
This work used direct intracranial electroencephalogram recordings from human epilepsy patients during natural sleep to test the assumption that SOs, spindles and ripples are functionally coupled in the hippocampus, and found thatSpindles were modulated by the up-state of SOs. Expand
Nucleus Accumbens Deep Brain Stimulation Decreases Ratings of Depression and Anxiety in Treatment-Resistant Depression
BACKGROUND While most patients with depression respond to combinations of pharmacotherapy, psychotherapy, and electroconvulsive therapy (ECT), there are patients requiring other treatments. DeepExpand
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
Preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. Expand
Sustained Neural Activity Patterns during Working Memory in the Human Medial Temporal Lobe
This work exploits intracranial EEG to identify WM-specific sustained activity patterns with the highest temporal and spatial resolution currently available in humans, and shows that these patterns depend on WM load. Expand
High-frequency neural activity and human cognition: Past, present and possible future of intracranial EEG research
Overall, iEEG research on HFA should play an increasing role in cognitive neuroscience in humans, because it can be explicitly linked to basic research in animals, and the future evolution of this field is discussed. Expand
Memory Consolidation by Replay of Stimulus-Specific Neural Activity
It is shown in healthy human participants that stimulus-specific activation patterns can indeed be identified with MVPA, that these patterns reoccur spontaneously during postlearning resting periods and sleep, and that the frequency of reactivation predicts subsequent memory for individual items. Expand
Ripples in the medial temporal lobe are relevant for human memory consolidation.
These data are the first recordings of ripples in humans during a cognitive task and suggest that ripples are indeed related to behavioural performance; they propose a mechanism for phase-locking of r ripple to neocortical slow waves via phase coupling to hippocampal delta activity and show that r ripple can be recorded reliably with standard macroelectrodes in the human brain. Expand
Phase/amplitude reset and theta–gamma interaction in the human medial temporal lobe during a continuous word recognition memory task
The broad‐band phase and amplitude reset was observed for both hits and correct rejections, and therefore, did not appear to support a specific cognitive function, but rather to act as a general facilitating factor for the processes involved in this memory task. Expand