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Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B.
UNLABELLED Genome-wide association studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The CVD-associated region isExpand
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Genome-wide association study of coronary artery disease in the Japanese
A new understanding of the genetic basis of coronary artery disease (CAD) has recently emerged from genome-wide association (GWA) studies of common single-nucleotide polymorphisms (SNPs), thus farExpand
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Absorption and metabolism of gamma-oryzanol in rats.
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Regulation of shortening velocity by calponin in intact contracting smooth muscles.
To elucidate the function of calponin in intact contracting smooth muscle cells in vivo, we generated mice with a mutated basic calponin (h1) locus (Yoshikawa et al., Genes Cells 3, 685-695, 1998).Expand
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Pravastatin Use and the Five-year Incidence of Cancer in Coronary Heart Disease Patients: from the Prevention of Coronary Sclerosis Study
BACKGROUND Although the short-term safety of statins is well established, their potential carcinogenicity in the long term is still being debated. The aim of this study was to investigate theExpand
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Therapeutic effect of taurine in congestive heart failure: A double‐blind crossover trial
In a double‐blind, randomized, crossover, placebo‐controlled study, we investigated the effects of adding taurine to the conventional treatment in 14 patients with congestive heart failure for aExpand
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Impact of cilostazol on restenosis after percutaneous coronary balloon angioplasty.
BACKGROUND Restenosis after percutaneous transluminal coronary (balloon) angioplasty (PTCA) remains a major drawback of the procedure. We previously reported that cilostazol, a platelet aggregationExpand
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Usefulness of taurine in chronic congestive heart failure and its prospective application.
We compared the effect of oral administration of taurine (3 g/day) and coenzyme Q10 (CoQ10) (30 mg/day) in 17 patients with congestive heart failure secondary to ischemic or idiopathic dilatedExpand
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Reduction of doxorubicin-induced cardiotoxicity in mice by taurine.
The effect of taurine on doxorubicin-induced cardiotoxicity was examined in mice. A single intraperitoneal injection of doxorubicin (15 mg/kg) produced a significant elevation of calcium andExpand
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Identification of the transcriptional regulatory sequences of human calponin promoter and their use in targeting a conditionally replicating herpes vector to malignant human soft tissue and bone
The calponin (basic or h1) gene, normally expressed in maturated smooth muscle cells, is aberrantly expressed in a variety of human soft tissue and bone tumors. In this study, we show that expressionExpand
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