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Characterization of a multicomponent receptor for GDNF
TLDR
It is demonstrated that physiological responses to GDNF require the presence of a novel glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-α) that is expressed on GDNF-responsive cells and binds GDNF with a high affinity, which supports the hypothesis that GDNF uses a multi-subunit receptor system in which GDN FR-α and Ret function as the ligand-binding and signalling components.
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Akt/PKB regulates actin organization and cell motility via Girdin/APE.
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A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor
TLDR
These findings identify Ret and NTNR-α as signalling and ligand-binding components, respectively, of a receptor for NTN and define a novel family of receptors for neurotrophic and differentiation factors composed of a shared transmembrane protein tyrosine kinase and a lig and-specific GPI-linked protein.
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An actin-binding protein Girdin regulates the motility of breast cancer cells.
TLDR
Girdin is expressed in a variety of cancer cell lines, including the breast cancer cell line MDA-MB-231, and is phosphorylated by the stimulation of insulin-like growth factor (IGF-I), highlighting the important role of Girdin in tumor progression in which the Akt signaling pathway is aberrantly activated.
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Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities
TLDR
The prediction accuracy of i-Score is as good as those of s-Biopredsi, ThermoComposition21 and DSIR, which employ a neural network model or more parameters in a linear regression model, and exclusion of thermostable siRNAs, whose whole stacking energy is less than −34.6 kcal/mol, improves the prediction accuracy.
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Roles of Disrupted-In-Schizophrenia 1-Interacting Protein Girdin in Postnatal Development of the Dentate Gyrus
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Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.
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A Mutation at Tyrosine 1062 in MEN2A-Ret and MEN2B-Ret Impairs Their Transforming Activity and Association with Shc Adaptor Proteins*
TLDR
Investigation of the role of tyrosine residues present in the carboxyl-terminal sequence for the transforming activity of Ret with the MEN 2A or MEN 2B mutation demonstrated that tyosine 1062 represents an autophosphorylation site of the mutant Ret proteins.
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Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis
TLDR
Etv4 and Etv5 are key components of a gene network downstream of Ret that promotes and controls renal branching morphogenesis, and several genes whose expression in the ureteric bud depends on them are identified.
View on Nature
The RET proto‐oncogene: A molecular therapeutic target in thyroid cancer
TLDR
The RET proto‐oncogene and some signaling molecules that function downstream of RET could be potential targets for the development of selective cancer therapeutics.
View on Wiley
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