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Coronary artery stretch versus deep injury in the development of in-stent neointima
Stretch of the coronary artery in a stent is common, and a major contributor to neointima formation, even in the absence of deep injury, although deep injury is a more potent stimulus to neointedima formation than stretch.
Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension
Genetic deletion of TRAIL or antibody blockade prevents the development of pulmonary arterial hypertension and can reverse vascular remodeling in established disease.
MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.
These studies identify both miR-140-5p and SMURF1 as key regulators of disease pathology and as potential therapeutic targets for the treatment of PAH.
Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension
Pulmonary artery denervation offers the possibility of a new treatment option for patients with pulmonary arterial hypertension and further work is required to determine the long-term efficacy and safety.
Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension
Immunohistochemical analysis of lung sections demonstrated imbalance in M1/M2 ratio in male MacLow mice only, suggesting that this imbalance may drive the PAH phenotype, and further implicate immune cells into this paradigm.
Hemodynamics and In-stent Restenosis: Micro-CT Images, Histology, and Computer Simulations
The direct comparison of hemodynamic parameters and biological response supports the hypothesis that low and oscillatory WSS lead to a greater neointimal response within the stented region and leads to a markedly non-uniform distribution of WSS values and correlates with asymmetric neo-intimal growth.
Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism
It is demonstrated that hypoxia preconditions the innate immune response and determines survival outcomes after bacterial infection through suppression of HIF-1α and neutrophil metabolism.
Toll‐like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension
A novel role is identified forTLR3 in PAH based on the findings that reduced expression of TLR3 contributes to endothelial apoptosis and pulmonary vascular remodeling.