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Coronary artery stretch versus deep injury in the development of in-stent neointima
- J. Gunn, N. Arnold, K. Chan, L. Shepherd, D. Cumberland, D. Crossman
- Biology, MedicineHeart
- 1 October 2002
Stretch of the coronary artery in a stent is common, and a major contributor to neointima formation, even in the absence of deep injury, although deep injury is a more potent stimulus to neointedima formation than stretch.
Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension
- A. Hameed, N. Arnold, A. Lawrie
- Biology, MedicineThe Journal of experimental medicine
- 22 October 2012
Genetic deletion of TRAIL or antibody blockade prevents the development of pulmonary arterial hypertension and can reverse vascular remodeling in established disease.
MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.
These studies identify both miR-140-5p and SMURF1 as key regulators of disease pathology and as potential therapeutic targets for the treatment of PAH.
Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner.
Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension
- A. Rothman, N. Arnold, A. Lawrie
- Medicine, BiologyCirculation. Cardiovascular interventions
- 1 November 2015
Pulmonary artery denervation offers the possibility of a new treatment option for patients with pulmonary arterial hypertension and further work is required to determine the long-term efficacy and safety.
Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension
- A. Zawia, N. Arnold, A. Lawrie
- Biology, MedicineArteriosclerosis, thrombosis, and vascular…
- 5 November 2020
Immunohistochemical analysis of lung sections demonstrated imbalance in M1/M2 ratio in male MacLow mice only, suggesting that this imbalance may drive the PAH phenotype, and further implicate immune cells into this paradigm.
Interleukin-1 receptor antagonist alters the response to vessel wall injury in a porcine coronary artery model.
Hemodynamics and In-stent Restenosis: Micro-CT Images, Histology, and Computer Simulations
- Stefano Morlacchi, B. Keller, P. Lawford
- Biology, EngineeringAnnals of Biomedical Engineering
- 22 July 2011
The direct comparison of hemodynamic parameters and biological response supports the hypothesis that low and oscillatory WSS lead to a greater neointimal response within the stented region and leads to a markedly non-uniform distribution of WSS values and correlates with asymmetric neo-intimal growth.
Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism
It is demonstrated that hypoxia preconditions the innate immune response and determines survival outcomes after bacterial infection through suppression of HIF-1α and neutrophil metabolism.
Toll‐like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension
- D. Farkas, A. Thompson, L. Farkas
- Biology, MedicineAmerican journal of respiratory and critical care…
- 15 January 2019
A novel role is identified forTLR3 in PAH based on the findings that reduced expression of TLR3 contributes to endothelial apoptosis and pulmonary vascular remodeling.