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Adenovirus Type 11 Uses CD46 as a Cellular Receptor
ABSTRACT The 51 human adenovirus serotypes are divided into six species (A to F). Many adenoviruses use the coxsackie-adenovirus receptor (CAR) for attachment to host cells in vitro. Species BExpand
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Adenovirus receptors: implications for tropism, treatment and targeting
  • N. Arnberg
  • Biology, Medicine
  • Reviews in medical virology
  • 1 May 2009
Adenoviruses (Ads) are the most frequently used viral vectors in gene therapy and cancer therapy. Obstacles to successful clinical application include accumulation of vector and transduction in liverExpand
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Adenovirus Type 37 Uses Sialic Acid as a Cellular Receptor
ABSTRACT Two cellular receptors for adenovirus, coxsackievirus-adenovirus receptor (CAR) and major histocompatibility complex class I (MHC-I) α2, have recently been identified. In the absence of CAR,Expand
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Initial Interactions of Subgenus D Adenoviruses with A549 Cellular Receptors: Sialic Acid versus αvIntegrins
ABSTRACT Selected members of the adenovirus family have been shown to interact with the coxsackie adenovirus receptor, αvintegrins, and sialic acid on target cells. Initial interactions of subgenus DExpand
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Crystal Structure of Species D Adenovirus Fiber Knobs and Their Sialic Acid Binding Sites
ABSTRACT Adenovirus serotype 37 (Ad37) belongs to species D and can cause epidemic keratoconjunctivitis, whereas the closely related Ad19p does not. Primary cell attachment by adenoviruses isExpand
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CD46 Is a Cellular Receptor for All Species B Adenoviruses except Types 3 and 7
ABSTRACT The 51 human adenovirus serotypes are divided into six species (A to F). Adenovirus serotypes from all species except species B utilize the coxsackie-adenovirus receptor for attachment toExpand
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Adenovirus type 11 binding alters the conformation of its receptor CD46
Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of itsExpand
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Avian influenza and sialic acid receptors: more than meets the eye?
Given our recent discoveries that the ocular human pathogens adenovirus serotype 37 and enterovirus serotype 70 use sialic acid linked to galactose via alpha2,3 glycosidic bonds as a cellularExpand
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Adenoviruses Use Lactoferrin as a Bridge for CAR-Independent Binding to and Infection of Epithelial Cells
ABSTRACT Most adenoviruses bind to the coxsackie- and adenovirus receptor (CAR). Surprisingly, CAR is not expressed apically on polarized cells and is thus not easily available to viruses.Expand
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Adenovirus receptors: implications for targeting of viral vectors.
  • N. Arnberg
  • Biology, Medicine
  • Trends in pharmacological sciences
  • 1 August 2012
Cancer, cardiovascular disease, and infectious diseases are all global health threats. To combat these diseases with gene therapies, adenovirus-based vectors have been developed. Although certainExpand
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