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Hydrogen Peroxide as a Paracrine Vascular Mediator: Regulation and Signaling Leading to Dysfunction
Numerous studies have demonstrated the ability of a variety of vascular cells, including endothelial cells, smooth muscle cells, and fibroblasts, to produce reactive oxygen species (ROS). Until… Expand
Comparison of H2O2-induced vasoconstriction in the abdominal aorta and mesenteric artery of the mouse.
Hydrogen peroxide (H(2)O(2)) is generally perceived as an arterial vasodilator. Due to the emerging importance of H(2)O(2) as a possible vasoconstrictor, we examined whether H(2)O(2) constricts both… Expand
Distinct hydrogen peroxide-induced constriction in multiple mouse arteries: potential influence of vascular polarization.
It is a matter of controversy whether the reactive oxygen species hydrogen peroxide (H(2)O(2)) contributes to tone in the vasculature as a vasodilator or vasoconstricting factor. To address this, we… Expand
Efficacy Of UR-63325, A New Histamine H4 Receptor Antagonist, In House Dust Mite-Induced Mouse Asthma Models
UR-60427, a novel H4 receptor-inverse agonist that shows good efficacy in a rat asthma model
Histamine H4 receptor (H4R) has an important role in immune and inflammatory diseases . A pivotal study by Dunford et al.  has shown that treatment with the H4R antagonist JNJ7777120 shows a… Expand
Myocardial Response to Biomechanical Stress
[Genetics and molecular biology in cardiology (IV). Myocardial response to biomechanical stress].
- J. Díez, B. López, A. González, N. Ardanaz, M. A. Fortuño
- Revista espanola de cardiologia
Biomechanical stress of the myocardium is the situation resulting from hypoxia, hypertension, and other forms of myocardial injury, that invariably lead to increased demands for cardiac work and/or… Expand