• Publications
  • Influence
Hydrogen Peroxide as a Paracrine Vascular Mediator: Regulation and Signaling Leading to Dysfunction
Numerous studies have demonstrated the ability of a variety of vascular cells, including endothelial cells, smooth muscle cells, and fibroblasts, to produce reactive oxygen species (ROS). UntilExpand
  • 221
  • 20
Comparison of H2O2-induced vasoconstriction in the abdominal aorta and mesenteric artery of the mouse.
Hydrogen peroxide (H(2)O(2)) is generally perceived as an arterial vasodilator. Due to the emerging importance of H(2)O(2) as a possible vasoconstrictor, we examined whether H(2)O(2) constricts bothExpand
  • 15
  • 3
Distinct hydrogen peroxide-induced constriction in multiple mouse arteries: potential influence of vascular polarization.
It is a matter of controversy whether the reactive oxygen species hydrogen peroxide (H(2)O(2)) contributes to tone in the vasculature as a vasodilator or vasoconstricting factor. To address this, weExpand
  • 24
  • 2
  • PDF
UR-60427, a novel H4 receptor-inverse agonist that shows good efficacy in a rat asthma model
Histamine H4 receptor (H4R) has an important role in immune and inflammatory diseases [1]. A pivotal study by Dunford et al. [2] has shown that treatment with the H4R antagonist JNJ7777120 shows aExpand
  • 8
[Genetics and molecular biology in cardiology (IV). Myocardial response to biomechanical stress].
Biomechanical stress of the myocardium is the situation resulting from hypoxia, hypertension, and other forms of myocardial injury, that invariably lead to increased demands for cardiac work and/orExpand
  • 4