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Staphylococcus aureus biofilms
The genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus, are explored. Expand
Vaccine development in Staphylococcus aureus: taking the biofilm phenotype into consideration
One of the better studied microbial species that uses differential, multifactorial protein profiles to mediate an array of diseases, Staphylococcus aureus, is used to outline some of the more recently identified problematic issues in vaccine development in this biofilm-forming species. Expand
Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses.
A previously unknown pathway by which S. aureus epicutaneous exposure to mouse skin promoted MyD88-dependent skin inflammation initiated by IL-36, but not IL-1α/β, IL-18, or IL-33 is defined. Expand
Clearance of Staphylococcus aureus Nasal Carriage Is T Cell Dependent and Mediated through Interleukin-17A Expression and Neutrophil Influx
The data suggest that the Th17-associated immune response is required for nasal decolonization and may be targeted for strategies to mitigate distal infections originating from persistent S. aureus carriage in humans. Expand
Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis
It is shown that LL37 binds to RNA from neutrophil extracellular traps (NETs), which amplifies inflammation and production of more LL37 and NETs via TLR8/13, suggesting that LL 37 contribution to psoriasis may be fueled by NET-associated RNA. Expand
Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
It is shown that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Expand
Mouse model of hematogenous implant-related Staphylococcus aureus biofilm infection reveals therapeutic targets
Significance Hematogenous implant-related infections are an important clinical problem because bacteria spread from the bloodstream to a previously well-functioning implant and result in infectiousExpand
IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin.
IL-22 is important for limiting the growth of S aureus on mechanically injured skin and caution that IL-23 and IL-22 blockade in patients with AD may enhance susceptibility to staphylococcal skin infection. Expand
Interleukin-17A (IL-17A) and IL-17F Are Critical for Antimicrobial Peptide Production and Clearance of Staphylococcus aureus Nasal Colonization
It is discovered that nasal tissue supernatants have antistaphylococcal activity, and mice deficient in both IL- 17A and IL-17F lost the ability to clear S. aureus nasal colonization. Expand
Comparative intravital imaging of human and rodent malaria sporozoites reveals the skin is not a species‐specific barrier
Pre‐clinical screening of next‐generation vaccines would be significantly aided by the in vivo platform presented here, expediting down‐selection of candidates prior to human vaccine trials, and suggesting that in contrast to the liver and blood stages, the skin is not a species‐specific barrier for Plasmodium. Expand