Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor.
- K. Miyazawa, H. Tsubouchi, O. Sakiyama
- Biology, ChemistryBiochemical and Biophysical Research…
- 15 September 1989
Evidence for the identity of human scatter factor and human hepatocyte growth factor.
- K. M. Weidner, N. Arakaki, Y. Daikuhara
- Biology, MedicineProceedings of the National Academy of Sciences…
- 15 August 1991
Structural and functional evidence is presented that human SF and human HGF are identical proteins encoded by a single gene and SF in fact acts as a hepatocyte growth factor, which stimulates DNA synthesis of activity and induces invasiveness of various epithelial cells.
Possible role of cell surface H+ -ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cells.
- N. Arakaki, T. Nagao, T. Higuti
- Biology, ChemistryMolecular Cancer Research
- 1 November 2003
The present results demonstrate that the use of small molecular H(+)-ATP synthase inhibitors targeting the F(1) catalytic domain may lead to significant advances in potential antiangiogenic cancer therapies.
Alkyl Gallates, Intensifiers of β-Lactam Susceptibility in Methicillin-Resistant Staphylococcus aureus
- H. Shibata, K. Kondo, T. Higuti
- BiologyAntimicrobial Agents and Chemotherapy
- 1 February 2005
It is clearly demonstrates that the length of the alkyl chain has a key role in the elevation of susceptibility to β-lactam antibiotics.
Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme‐linked immunosorbent assay
- H. Tsubouchi, Y. Niitani, Y. Daikuhara
- Medicine, BiologyHepatology
- 1 January 1991
Serum human hepatocyte growth factor levels in patients with acute hepatitis, chronic hepatitis and cirrhosis were found to be slightly higher than those in normal subjects, but only the increase in serum human hepatocytes growth factor of acute hepatitis patients was statistically significant.
Cell‐surface H+‐ATP synthase as a potential molecular target for anti‐obesity drugs
- N. Arakaki, Toshiyuki Kita, H. Shibata, T. Higuti
- Biology, ChemistryFEBS Letters
- 24 July 2007
Triple Combinations of Lower and Longer Alkyl Gallates and Oxacillin Improve Antibiotic Synergy against Methicillin-Resistant Staphylococcus aureus
- H. Shibata, T. Nakano, T. Higuti
- BiologyAntimicrobial Agents and Chemotherapy
- 17 February 2009
Combinations of these gallates remarkably reduced oxacillin MICs against methicillin-resistant Staphylococcus aureus to below the antibiotic breakpoint (≤2 μg/ml).
Dynamics of mitochondria during the cell cycle.
- N. Arakaki, Takeshi Nishihama, T. Higuti
- BiologyBiological and Pharmaceutical Bulletin
- 1 September 2006
Mitochondria are highly dynamic organelles in eukaryotic cells. Although the role of mitochondria in metabolism, ATP production and apoptosis is more widely recognized, alterations in mitochondrial…
Possible role of mitochondrial remodelling on cellular triacylglycerol accumulation.
- Toshiyuki Kita, H. Nishida, H. Shibata, S. Niimi, T. Higuti, N. Arakaki
- BiologyJournal of Biochemistry (Tokyo)
- 1 December 2009
The results suggest that cellular TG accumulation is regulated, at least in part, via mitochondrial fusion and fission processes, and polyphenolic phytochemicals, negative regulators of lipid accumulation, have mitochondrial fusion activity.
Expression of HGF/SF in mesothelioma cell lines and its effects on cell motility, proliferation and morphology.
HGF/SF may well stimulate the growth and spread of malignant mesothelioma in vivo by paracrine and/or autocrine mechanisms.
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