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Interactions of Human Organic Anion Transporters and Human Organic Cation Transporters with Nonsteroidal Anti-Inflammatory Drugs
TLDR
It was suggested that the interactions of hOATs with NSAIDs are associated with the pharmacokinetics and the induction of adverse reactions of NSAIDs.
Interactions of Human Organic Anion Transporters with Diuretics
TLDR
HOAT1 may play an important role in the basolateral uptake of thiazides, and hOAT3 in the uptake of loop diuretics, and it was suggested that bumetanide taken up by hO AT3 and/or hOat1 is excreted into the urine by h OAT4.
The Multivalent PDZ Domain-containing Protein PDZK1 Regulates Transport Activity of Renal Urate-Anion Exchanger URAT1 via Its C Terminus*
TLDR
The present study indicates the novel role of PDZK1 in regulating the functional activity of URAT1-mediated urate transport in the apical membrane of renal proximal tubules.
Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules.
TLDR
OAT4 is an apical organic anion/dicarboxylate exchanger and mainly functions as a apical pathway for the reabsorption of some organic anions in renal proximal tubules driven by an outwardly directed dicar boxylate gradient.
Plasma Urate Level Is Directly Regulated by a Voltage-driven Urate Efflux Transporter URATv1 (SLC2A9) in Humans*
TLDR
It is reported that a sugar transport facilitator family member protein GLUT9 (SLC2A9) functions as an efflux transporter of urate from the tubular cell and is proposed to be renamed URATv1 (voltage-driven urate transporter 1).
Identification of a Novel System L Amino Acid Transporter Structurally Distinct from Heterodimeric Amino Acid Transporters*
TLDR
A cDNA that encodes a novel Na+-independent neutral amino acid transporter was isolated from FLC4 human hepatocarcinoma cells by expression cloning and proposed to be a transporter subserving system L2, a new family of organic solute transporters.
New insights into renal transport of urate
TLDR
Current evidence is insufficient to fully understand the precise mechanism governing the bi-directional transport of urate, so a new concept of renal urate transport is proposed: urate-transporting multimolecular complex, or ‘urate transportsome’.
l‐Type amino acid transporter 1 inhibitors inhibit tumor cell growth
TLDR
KYT‐0353 appears to have potential as a novel anti‐tumor agent, presumably via selective in vivol‐type amino acid transporter 1 inhibition, according to in vitro and in vivo studies.
Molecular Identification of a Novel Carnitine Transporter Specific to Human Testis
TLDR
The identification of CT2 represents an interesting evolutionary link between OCT/OCTNs and OATs, as well as provides an important insight into the maturation of human spermatozoa.
Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins.
TLDR
The functional activity of OAT4 is modulated through the PDZ interaction with the network of PDZK1 and NHERF1 and suggests that Oat4 is involved in the regulated apical organic anion handling in the renal proximal tubules, provided by the PDz scaffold.
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